Immunology Review Corner

Immunology Review Corner: chapter reviews of the 5th edition of Cellular and Molecular Immunology, edited by Abul K. Abbas and Andrew H. Lichtman.

Chapter 3

1. All of the following statements about structural features of immunoglobulin molecules are true EXCEPT
a. The most variable region is the CDR3
b. In human IgM and IgE antibodies, the C regions contain four tandem Ig domains
c. The three hypervariable region of VL domain and three hypervariable region of VH domain are brought together in three dimensional space to form an antigen-binding surface
d. V region of the heavy chains mediate effector functions
e. There are no known differences in function between kappa containing antibodies and lambda containing antibodies

2. At what state in B-cell development is cytoplasmic m (mu) heavy chain first seen?
a. Stem cell
b. Pre-B cell
c. Immature B cell
d. Mature B cell
e. Antibody secreting cell

3. Antibody molecules can be divided into distinct classes based on differences in the heavy chain constant regions. These classes are called:
a. Allotypes
b. Isotypes
c. Idiotypes
d. Complementary determining regions
e. Phenotypes

4. What is the most commonly produced antibody in a healthy adult on a daily basis?
a. IgA
b. IgE
c. IgG
d. IgD
e. IgM

5. What is the most common type of antibody found in the serum?
a. IgA
b. IgE
c. IgG
d. IgD
e. IgM

6. Which antibody functions predominantly in mucosal immunity?
a. IgA
b. IgE
c. IgG
d. IgD
e. IgM

7. Which antibody or antibodies function(s) as a naïve B cell antigen receptor?
a. IgD
b. IgG
c. IgM
d. A and C
e. B and C

8. Effector mechanisms of humoral immunity include all of the following EXCEPT:
a. alternative pathway of compliment
b. neutralizing toxins
c. opsonization of antigens
d. ADCC
e. immediate hypersensitivity

9. The cytoplasmic region of membrane bound antibody includes:
a. N-terminus
b. Fab
c. C-Terminus
d. disulfide bonds
e. hypervariable regions

10. The process by which B cells develop antibodies with greater affinity to a previously recognized antigen:
a. memory
b. isotype switching
c. antibody repertoire
d. affinity maturation

11. The tissue distribution of antibody is determined by
a. heavy chain
b. light chain
c. Kappa chain
d. V regions
e. N-terminus

12. The most variable region of the antigen-binding site of antibodies is known as:
a. CDR2
b. CDR3
c. CL
d. CH3

13. Humanized antibodies, in which DNA segments encoding the antigen-binding sites from a murine monoclonal antibody are ‘spliced’ into cDNA encoding a human myeloma protein, are designed to try to circumvent what problem?

a. Production of human anti-mouse antibody (HAMA)
b. Production of anti-idiotype antibody
c. Decreased murine antibody Fc effector functions in humans
d. Decreased serum half-life of murine antibody in humans
e. None of the above

14. All of the following are features of antigen binding by TCR molecules EXCEPT:
a. Binds linear determinants of peptides only
b. Binds linear determinants of peptides and other macromolecules
c. Binds conformational determinants of peptides only
d. Binds conformational determinants of peptides and other macromolecules
e. None of the above

15. All of the following are members of the immoglobulin Superfamily EXCEPT:
a. IgG
b. Class II MHC
c. B7-1/B7-2
d. IL-1R
e. IL-2R

16. The serum half-life of IgE is:
a. 2 days
b. 5 days
c. 6 days
d. 23 days
e. 35 days

17. Cleavage products from rabbit IgG digestion with Papain are:
a. F(ab’)2 and various peptide fragments
b. F(ab’)2 and one Fc fragment
c. Two Fab fragments and various peptide fragments
d. Two Fab fragments and one Fc fragment
e. Rabbit IgG is completely digested into various small peptide fragments

ANSWERS:
1. D pg 52-55
2. B pg 58 figure
3. B pg 54 box
4. A pg 44
5. C pg 44
6. A pg 53
7. D pg 53
8. A pg 43-44
9. C pg 48
10. D pg 62
11. A pg 63
12. B pg 49-50
13. A pg 45-47
14. A pg 44
15. E pg 50-51
16. A pg 52-53
17. D pg 55-57