Immunology Review Corner

Immunology Review Corner: chapter 4 review of the 5th edition of Cellular and Molecular Immunology, edited by Abul K. Abbas and Andrew H.
Lichtman.

By Nathanael Horne, M.D.
Fellow-In-Training, Allergy and Immunology
Nassau University Medical Center

1. MHC Class I Genes include:
a. HLA A
b. HLA B
c. HLA C
d. HLA DR
e. a,b,and c

2. MCH Class II molecules are generally recognized by which cells:
a. CD8+ Tcells
b. CD4+ Tcells
c. Erythrocytes
d. Neutrophils

3. The non-polymorphic portion of MCH molecule contain:
a. polymorphic regions for binding presented peptide sequences
b. binding sites for CD4+, CD8+ T-cells
c. the invariant chain
d. TAP

4. The location of the polymorphic residues on the MHC Class II molecule
a. alpha-2 and beta-2 domains
b. alpha-1 and alpha-2 domains
c. alpha-1 and beta-1 domains
d. alpha-1 and beta-1 domains
e. beta-2 microglobulin

5. MHC Class I molecules accommodate peptide residues:
a. 8-11 resides
b. 10-30 residues
c. 60-80 residues
d. 3-4 residues

6. When full assembled the MHC class I molecules is composed of what chains?
a. alpha and beta chains
b. delta and gamma chains with peptide
c. alpha and beta-2 microglobulin chains
d. alpha and beta-2 microglobulin chains with bound antigenic peptide
e. beta-pleated sheet supported by two parallel strands of alpha-helix

7. What is the binding site on the MHC molecule for the T cell coreceptor CD8?
a. alpha-3 region
b. beta-2 region
c. alpha-1 and alpha-2 domains
d. beta-3 domain
e. alpha-1 and beta-1 domains

8. What is the binding site on the MHC molecule for the T cell coreceptor CD4?
a. alpha-3 region
b. beta-2 region
c. alpha-1 and alpha-2 domains
d. beta-3 domain
e. alpha1 and beta-1 domains

9. When full assembled the MHC class II molecules is composed of what chains?
a. alpha and beta chains
b. delta and gamma chains with peptide
c. alpha and beta-2 microglobulin chains
d. alpha and beta-2 microglobulin chains with bound antigenic peptide
e. beta-pleated sheet supported by two parallel strands of alpha-helix


10. MHC Class II molecules accommodate peptide residues:
a. 8-11 resides
b. 10-30 residues
c. 60-80 residues
d. 3-4 residues

11. What is the function of anchor residues?
a. Bind firmly to CD8 or CD4 coreceptors to increase TCR affinity.
b. Bind to either alpha or beta chains to maintain the overall structure of the MHC molecule
c. They form the conserved regions that the TCR binds to upon antigen presentation
d. Antigen peptide residues that bind to the alpha-helices and beta-strands on the MHC securing the antigen peptide in the binding groove
e. Serve as signal transducers upon antigen presentation and t cell activation

12. With regards to T cell antigen recognition which of the following is a true statement?
a. Amino acids from both the antigenic peptide and the MHC molecules contribute to T cell antigen recognition
b. The MHC molecule is responsible for the fine specificity of antigen recognition as well as MHC restriction of the T cells
c. Only the amino acids from the antigenic peptides are responsible for T cell antigen recognition
d. The interaction of CD4 with the MHC class II molecule is responsible for the fine specificity of antigen recognition
e. The fine specificity of antigen recognition is due to anchor residues unique to MHC class II molecules

13. In humans, what chromosome are the MHC genes located on?
a. Short arm of chromosome 2
b. Short arm of chromosome 6
c. Chromosome 15
d. Chromosome 4
e. Chromosome 7

14. There are genes between the class I and class II clusters that code for several proteins important to the immune system. These genes are referred to as?
a. MHC-like genes
b. Immune response genes
c. MHC class III genes
d. Leukocyte trafficking genes
e. The cluster of differentiation

15. Several transcription factors that bind class II promoter regions can increase the expression of MHC molecules. Mutations in these transcription factors result in immunodeficiency disease associated with defective expression of MHC molecules. Which syndrome listed is the best studied of these disorders?
a. Wiskott-Aldrich Syndrome
b. Ommen’s Syndrome
c. Bare lymphocyte Syndrome
d. common gamma chain deficiency
e. ZAP-70 deficiency

ANSWERS
1. e, pg. 69
2. a, pg. 69
3. b, pg. 69
4. c, pg. 70
5. a, pg. 70
6. d, pg. 71
7. a, pg. 70, table 4-1
8. b, pg. 70, table 4-1
9. a, pg. 72
10. b, pg. 72 and 74
11. d, pg. 75
12. a, pg. 75
13. b, pg. 76
14. c, pg. 76
15. c, pg. 79