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Parent assessments
about child HRQL
reliable, study says.

Older patients
with asthma
cope better.

 
April 12, 2006
 
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Top Stories
 
Parent reports accurate in children’s drug trials
Parental assessments are reliable sources of information about a child's health-related quality of life (HRQL), in lieu of children’s assessments, when they’re unable to complete the assessments, according to a study in Cancer. Researchers from St. Jude's Children's Research Hospital in Memphis, Tenn., reviewed 199 children assessed either during or after cancer treatment and 108 healthy children. In all cases, both the children and their parents completed HRQL assessments. The researchers found that in each of the 10 HRQL measures, parents and children answered similarly. The correlation was most consistent among families of children with cancer. 

Older asthma patients cope with disease better
Older asthma patients may fare better than younger asthma patients, according to a Missouri study in the Annals of Allergy, Asthma and Immunology. Researchers at Saint Louis University examined data from a 3-year observational study of more than 4,700 patients with severe asthma, comparing 566 patients, who were 65 or older, with 2,912 patients, who were 18 to 64 years old. The older group had significantly lower lung function (FEV1) but significantly fewer unscheduled office visits and emergency room visits than the younger patients. Overall, they used health care resources less than the younger patients. The older patients also used more inhaled corticosteroids and reported better quality of life than the younger patients.

Smoking in different room doesn’t protect kids with asthma
Parents who merely move to a different room to smoke in the home don’t protect asthmatic children much, according to a study in Ambulatory Pediatrics. Researchers at the University of Rochester (N.Y.) Medical Center surveyed 231 parents of children with persistent and severe asthma. Almost half of the children lived in a home with a smoker. Among all the families, 64 percent enforced strict no-smoking rules in both the home and car. Among families with smokers, only 40 percent had such rules. Children with severe asthma were no more likely to live in a home with no smoking than children with less severe asthma.  

  
A word from guest writer, Nancy Sander, president, AANMA

It was with enormous concern that I watched the April 6, 2006, NBC “Today Show” segment in which Katie Couric interviewed Forbes journalist Robert Langreth regarding his "Trouble Breathing" article about Advair. I am the president and founder of Allergy & Asthma Network Mothers of Asthmatics (AANMA), a leading patient education and advocacy organization since 1985. I also am a member of the FDA advisory panel that reviewed issues relating to Advair, as well as the 12-hour bronchodilators Serevent and Foradil.

I believe the Forbes story is not grounded in science and is likely to spark a feeding frenzy among lawyers willing to victimize grieving families. Furthermore, the story strikes fear in the hearts of patients and their families, who now doubt the safety of their medications, the prescribing decisions of their physicians, and the integrity of the Food and Drug Administration — all needlessly.

Asthma kills 13 people every day; one-third are diagnosed with mild forms of the disease, one-third with moderate and one-third with severe symptoms. Most asthma deaths are preventable.

Of the deaths reported in the Forbes story, it is not possible to pin cause and effect on Advair. Making such a determination requires extensive investigation. On the surface, it would appear that at least two deaths can be attributed to using the wrong medication during an acute episode. Such 12-hour bronchodilators are not intended to halt an attack in progress.

In an attempt to understand why asthma deaths occur, the Allergy & Asthma Network Mothers of Asthmatics has spent 20 years studying patient and physician interactions and have determined that communication gaps in the doctor's office often leave patients unprepared to treat or prevent asthma emergencies.

Barriers to care affecting all people with asthma include:
• artificially imposed drug formularies, which prioritize access to medications based on price
• restricted access to specialists and diagnostic testing procedures
• lack of continuity of care
• too little time for meaningful communication necessary for customizing care to individual patients

I am thankful that the Food and Drug Administration requires post-marketing research and that pharmaceutical manufacturers must comply with regulations. As a member of the FDA advisory board representing the concerns of patients with asthma and their families, I received training to understand the complexities and vulnerabilities of our existing drug approval and monitoring process. For the most part, it works well. But it is not perfect.

Because we receive numerous e-mail messages and phone calls regarding Advair, Serevent and Foradil, AANMA staff and medical editors, Drs. Michael Mellon and Stuart Stolloff, wrote, "Twelve-Hour Bronchodilators: What Patients Want To Know," published in the Winter 2006 issue of AANMA's quarterly magazine, Allergy & Asthma Today. ACAAI members are welcome to add to your Web pages a link to the article, which is posted on AANMA's Web site, or download and print copies of the article to provide your patients:
http://www.aanma.org/news/news.asp?StoryId=580&CategoryId=1&sec=aanma

We are extremely concerned that the “Today Show” and Forbes stories are more likely to cause harm than good. It is important that we address the life-and-death facts of 12-hour bronchodilators — not the hype. The Forbes article is fraught with error. I believe that it's irresponsible reporting. Of the 13 patients who die from asthma today, how many will die because they stopped taking their Advair after watching the “Today Show” story?

Nancy Sander
President and Founder
Allergy & Asthma Network
Mothers of Asthmatics
nsander@aanma.org
  
Come to Athens for the ACAAI-HSACI meeting
The Joint Allergy Symposium of the ACAAI and Hellenic Society of Allergy & Clinical Immunology (HSACI), Sept. 6-9, offers the opportunity to attend a state-of-the-art scientific program, Allergy Update in Greece, while visiting the enchanting city of Athens.

This international meeting brings together many of the finest researchers and clinicians to present cutting-edge lectures on the most important topics for the clinical practice of allergy and immunology.

Plan to join your colleagues in Athens, one of the most exciting cities in the world, the metropolis of wisdom, philosophy and inspiration. The modern Athens Ledra Marriott Hotel is the perfect venue for this meeting, with its spacious conference center and view of the Acropolis.
  
Drugs and Devices
  
FDA approves second drug to prevent flu
The inhaled antiviral drug zanamivir (brand name Relenza) has been approved to prevent influenza in adults and children 5 years and older, the U.S. Food and Drug Administration announced recently.

Zanamivir is the second drug approved to both treat and prevent flu, the FDA said in its statement. The agency warned that people with asthma and other lung diseases shouldn't use Relenza, as they may be at higher risk of developing a dangerous bronchospasms. The drug is not a substitute for the flu vaccine.
  
Association News
  
NFID issues Call to Action to increase immunization rates in children with asthma
The ACAAI joins more than 15 of the nation’s leading medical and public health organizations in support of a Call to Action issued by the National Foundation for Infectious Diseases (NFID) to improve influenza vaccination rates in children with asthma.

The Call to Action is part of a new NFID initiative to explore barriers to immunization and identify strategies that can help improve national vaccination rates among this group. Despite long-standing Centers for Disease Control and Prevention (CDC) recommendations that call for annual influenza vaccination among children with asthma, estimates reveal only one-third of this high-risk population is immunized.

The CDC’s Advisory Committee on Immunization Practices (ACIP) recently voted to expand annual influenza immunization recommendations for all children 6 months to 5 years of age. Along with healthy children aged 2 to 5 years, children in this age group with chronic medical conditions — including asthma — are at an increased risk for influenza-related complications.

NFID’s Influenza and Children with Asthma initiative is made possible by an unrestricted educational grant to the NFID from sanofi pasteur.

Members in the spotlight
Dr. Stanislaus Ting from Las Cruces, N.M., received the American Medical Association (AMA) Foundation’s 2006 Leadership Award, which provides medical students, residents/fellows, young physicians and international medical graduate physicians special training to develop their skills as future leaders in organized medicine.

Recipients of the award demonstrate outstanding non-clinical leadership skills in advocacy, community service and/or education. The awards are presented in association with the Pfizer Medical Humanities Initiative.

Dr. Ting is the founder and medical director of St. Luke’s Clinic, which has provided free medical care to thousands of working poor and homeless in Las Cruces since 1991. He also is involved in humanitarian projects in Mexico and Thailand. He is a lifetime member of AMA and received the 2004 New Mexico Medical Society Community Service Award. Dr. Ting designed and published the first low-cost pragmatic asthma tool known as MSAGR (Multi-colored Simplified Asthma Guidelines Reminder) that has been disseminated globally for clinicians in the trenches to improve their adherence to asthma guidelines.

Have you written a new book? Have you won a prestigious award? Are you doing something that ACAAI members would really find interesting? Submit notable achievements and read about those of your peers in ACAAI eNews. Please e-mail member news notices to joannfaber@acaai.org.

New initiative supports frontline workers
A new national initiative, Jobs to Careers: Promoting Work-Based Learning for Quality Care, supports the needs of workers delivering direct health care and services (such as medical assistants, health educators and laboratory technicians in Allergy-Immunology), their employers, and the people they serve.

The initiative seeks to create lasting improvements in the training and advancement of frontline workers, and test new models of work-based rewards learning. Proposals for the program — established by the Robert Wood Johnson Foundation (RWJF) in collaboration with The Hitachi Foundation — are accepted through May 18, 2006.
  
Fellows-in-Training
  
Immunology Review Corner
Welcome to the Board Review Corner, prepared by Dr. Karla R. Davis, senior representative of ACAAI’s fellows-in-training (FITs) to the Board of Regents. The Board Review Corner is your chance to test your Board preparedness.

To refer to a previous Board Review Corner, click the “Archive” link in the left column.

Immunology Review Corner: Chapter 66 of the 6th edition of Middleton’s Allergy Principles and Practice, edited by N. Franklin Adkinson, et al. Review questions were written by Drs. Eric Chenworth, Mayo Clinic; Karla R. Davis, Walter Reed Medical Center; Anne K. Ellis, McMaster University. 
  
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