Allergy and Immunology
Review Corner

Chapter 4 of Pediatric Allergy: Principles & Practices, edited by Donald Y.M. Leung, et al.

Chapter 4: Regulation and Biology of Immunoglobulin E

Prepared by Drs. Bret Haymore and Soo Hee Kim-Delio at Walter Reed Army Medical Center.

1. The two cytokines that are most important for IgE isotype switching:
A. IL-4 & IL-10
B. IL-4 & IL-5
C. IL-4 & IL-13
D. IL-4 & IL-6

2. Which chain is shared by both the IL-4 and IL-13 receptors?
A. IL-4R-alpha chain
B. IL-13R-alpha1
C. IL-13R-alpha2
D. Common gamma chain

3. The transcription factors that are most associated with Th2 differentiation:
A. T-bet & STAT-4
B. T-bet & STAT-6
C. GATA-3 & STAT-6
D. NFAT & STAT-4

4. The transcription factors that are most associated with Th1 differentiation:
A. T-bet & STAT-4
B. T-bet & STAT-6
C. GATA-3 & STAT-6
D. NFAT & STAT-4

5. The second signal most important for IgE isotype switching involves:
A. CD80/86 (on B cell) & CD28 (on T cell)
B. CD80/86 (on T cell) & CD28 (on B cell)
C. CD40 (on T cell) & CD154 (on B cell)
D. CD40 (on B cell) & CD 154 (on T cell)

6. Production of which cytokine is a critical distinguishing feature of dendritic cell 1 (DC1)?
A. IL-4
B. IL-12
C. IL-10
D. GM-CSF

7. Which chain of the FcEpsilonRI binds IgE?
A. Alpha chain
B. Beta chain
C. Gamma chain
D. Delta chain

8. There are two isoforms of the FcEpsilonRI receptor, the tetrameric alpha-beta-gamma2 forms is found on:
A. Mast cells & eosinophils
B. Mast cells & basophils
C. Mast cells & dendritic cells
D. Eosinophils, platelets, monocytes, dendritic cells

9. What is distinctive about CD23?
A. It’s common designation is as “the other high affinity” IgE receptor
B. It has a low affinity for IgE with a Ka of about 1,000
C. It is only expressed on eosinophils
D. It is the only Ig receptor not in the Ig superfamily

10. Which of the following is a true statement about IgE regulation of receptors?
A. It alters transcription of mRNA encoding CD23
B. It alters transcription of mRNA encoding the FcEpsilonRI subunit
C. It modulates receptor turnover and proteolytic shedding
D. It alters the transcription of mRNA of both CD23 and the FcEpsilonRI subunit

Answers
1. C, page 40
2. A, page 40
3. C, page 43
4. A, page 43
5. D, page 41
6. B, page 44
7. A, page 45
8. B, page 45
9. D, page 45
10. C, page 46