Allergy and Immunology
Review Corner

Chapter 3 of Pediatric Allergy: Principles & Practices, edited by Donald Y.M. Leung, et al.

Chapter 3: The Genetics of Allergic Diseases & Asthma

Prepared by Drs. Bret Haymore, Jiun Yoon and Soo Hee Kim-Delio at Walter Reed Army Medical Center.

1. Which of the following is not encoded in chromosome region 5q?
A. ADAM33
B. IL-4
C. Beta2-adrenergic receptor
D. CD14

2. In what tissue is ADAM 33 expressed?
A. Bronchial epithelial cells
B. T-cells
C. Bronchial smooth muscle
D. Inflammatory leukocytes

3. Which of the following genes is most associated with atopic dermatitis?
A. CD14
B. ADAM 33
C. MODY
D. SPINK5

4. Which of the following genes has the most evidence in playing a role in airway remodeling?
A. Beta2-adrenergic receptor
B. CD14
C. A disintegrin and metalloprotease 33
D. SPINK5

5. Which of the following genes is most likely to reduce the risk of atopy by promoting a Th1 differentiation through innate responses?
A. A Disintegrin and Metalloprotease 33
B. IL-13
C. SPINK5
D. CD14

6. In seeking to identify genes that are causal of complex genetic diseases such as asthma, what is the greatest challenge?
A. Finding linkage of genetic loci with atopy or asthma
B. Securing grant money
C. Identifying genes that underlie the linkages identified
D. Not enough researchers studying asthma

7. Which gene has been identified as the cause of Netherton’s syndrome, a severe autosomal recessive disorder of congenital icthyosis with defective cornification?
A. LEKT1
B. SPINK5
C. ADAM33
D. MODY

Answers
1. A, pages 29-30
2. C, page 30. It is also expressed myofibroblasts and fibroblasts.
3. D, pages 33-34
4. C, page 30
5. D, page 33
6. C, page 28
7. B, page 33, SPINK5 encodes the serine proteinase inhibitor LETK1 on Chromosome 5q32