Allergy and Immunology
Review Corner

Allergy and Immunology Review Corner: Chapter 90 of the 6th edition of Middleton’s Allergy Principles and Practice, edited by N. Franklin Adkinson, et al.

Questions prepared by Dr. Soo Kim-Delio, Walter Reed Army Medical Center.

Chapter 90: Adverse Reactions to Food and Drug Additives

1. “EAFUS” is published by the FDA periodically. What does it stand for?
A. Eaten and Functional Unknown substances
B. Everything added to food in the United States
C. Everything about foods that’s used
D. Eats and Feed in the United States

2. What is the estimated occurrence of food additive allergy?
A. 0.01-0.24 percent
B. 0.5 percent
C. 1 percent
D. 2 percent

3. What component of some corticosteroid solutions has been reported as a cause of anaphylactic shock?
A. Gums (Arabic and tragacanth)
B. Ethylenediamine
C. Carboxymethyl cellulose
D. Thermosol

4. What component of antihistamines and corticosteroid tablets is an emulsifier that has caused urticaria?
A. Gums (Arabic and tragacanth)
B. Ethylenediamine
C. Carboxymethyl cellulose
D. Thermosol

5. Which of the following is a component of aminophylline, but is primarily associated with contact dermatitis and cutaneous sensitization?
A. Gums (Arabic and tragacanth)
B. Ethylenediamine
C. Carboxymethyl cellulose
D. Thermosol

6. Which preservative is often a contact sensitizer, but has caused anaphylaxis when administered in IV heparin solution?
A. Gums (Arabic and tragacanth)
B. Ethylenediamine
C. Carboxymethyl cellulose
D. Thermosol

7. Which of the following natural food colorants is an extract of the seeds of the fruit of the Bixa orellana tree?
A. Annatto
B. Carmine
C. Sulfites
D. Tartrazine

8. Which of the following is derived from dried female insects of Dactlopius coccus Costa, a parasite on the prickly pear cactus, and is used widely in cosmetics?
A. Annatto
B. Carmine
C. Sulfites
D. Tartrazine

9. Which of the following has </= 10 ppm of estimated total sulfite level?
A. Dried fruit
B. Wine
C. Nonfrozen lemon and lime juice
D. Malt vinegar

10. Which of the following is sometimes used as a vaccine expander?
A. Lactose
B. Beef and pork gelatin
C. Inulin
D. Wheat starch

Answers
1. C, page 1645
2. A, page 1646
3. C, page 1646
4. A, page 1646
5. B, page 1646
6. D, page 1646
7. A, page 1652
8. B, page 1652
9. D, page 1654
10. B, page 1660