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Human stem cells fuse with pig cells



ASBMT journal
begins Web-based
manuscript acceptance

  
February 2, 2004
  
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Clinical Research
   
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Tandem BMT Meetings
Feb 13 - 17, 2004
Orlando, Florida

 
 
ASBMT Monthly Poll
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Last Month's Poll Results

The Tandem BMT Meetings are traditionally held in February. Would you be interested in convening the meetings on a privately booked cruise ship in the Caribbean?
Yes. I’d like to do this, if the price is right. (56)
8%
   
I’m not really sure. It would be difficult for participants and speakers who want to attend only a portion of the meetings. (123) 18% 
   
No. Holding the meetings at sea has little appeal to me. (503) 74%
   
Other (Please see "comments") (1)
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Calendar

February
6th International Congress on New Trends in Immunosuppression
Feb. 5-8
Salzburg Congress Centre
Salzburg, Austria

Tandem BMT Meetings
(Combined ASBMT and IBMTR/ABMTR annual meetings)

Feb. 13-17
Coronado Springs Resort
Orlando, Fla.

March
American Association for Cancer Research (AACR)
95th Annual Meeting

March 27-31
Orange County Convention Center
Orlando, Fla.

European Group for Blood and Marrow Transplantation (EBMT)
30th Annual Meeting

March 28 - 31
Palau de Congressos de Catalunya
Barcelona, Spain

April
American Society of Pediatric Hematology/Oncology (ASPH/O)
17th Annual Scientific Meeting

April 29-May 2
Westin St. Francis Hotel
San Francisco

May
International Society for Cellular Therapy (ISCT)
10th Annual Meeting

May 7-10
The Burlington Hotel
Dublin, Ireland

American Society of Transplantation (AST)
American Transplant Congress

May 14-19
Hynes Convention Center
Boston

World Marrow Donor Association (WMDA)
5th International Donor Registry Conference

May 26-29
Keio University Mita Campus
Tokyo, Japan

• June
Canadian Blood and Marrow Transplant Group (CBMTG)
Biennial Meeting

June 3-6
London Convention Centre
London, Ontario

American Society for Clinical Oncology (ASCO)
40th Annual Meeting

June 5-8
Ernest N. Morial Convention Center
New Orleans

International Society for Stem Cell Research (ISSCR)
2nd Annual Meeting

June 10-13
Boston Seaport Hotel
Boston

• July
Federation of Clinical Immunology Societies (FOCIS)
4th Annual Conference

July 18-23
Palais de Congres de Montreal
Montreal, Quebec

International Society for Experimental Hematology (ISEH)
33rd Annual Scientific Meeting

July 17-20
New Orleans Marriott
New Orleans

2005
Tandem BMT Meetings
(Combined ASBMT and IBMTR/ABMTR annual meetings)

Feb. 10-14
Keystone Resort
Keystone, Colo.

 
  
Top Stories
 
Human stem cells fuse with pig cells
Adult pigs grown from fetuses that were injected with human stem cells have been found to contain pig cells, human cells and hybrid cells in which DNA from the two species is mixed at the cellular level. Scientists at the Mayo Clinic in Rochester, Minn., also found that porcine endogenous retrovirus was present in the hybrid cells, which can then infect human cells.
   
Japanese scientists create human embryonic stem cells
Scientists at Kyoto University’s Institute for Frontier Medical Sciences have become the first Japanese researchers to create human embryonic stem cells, following approval of the research in April 2002. They have developed three lines using mouse feeder cells and are awaiting government approval to begin distributing the cells for research purposes.
 
Researchers develop gel, use it to grow neural stem cells
Scientists at Northwestern University have grown neural stem cells in a specially engineered gel that could be injected directly at the site of spinal damage, according to a study published Jan. 22 on the Web site of the journal Science. The technique is still being tested in mice.
 
 

A Word from President Joseph Antin, M.D.

Whatever my opinion of Florida and its electoral machine has been, I am looking forward to escaping from the arctic air mass that has been torturing us this winter here in the Northeast. Even a moderately sunny week in Orlando at the Tandem BMT Meetings this month will be a welcome respite.

Along those lines, I have particularly good news about the 2006 meetings. We have signed contracts for the convention center and hotels in Honolulu. Not only will this be fun as a change of pace, but I hope that it will encourage participation from Asian and Australian investigators.

One of the privileges of being president of our Society this year has been chairing a committee that reviews applications for the ASBMT new investigator awards. We had a spectacular group of applications. While it was a pleasure to review this science, it was tempered by the understanding that we can support only a couple of awards out of the 29 research proposals. I would like to congratulate all of the applicants for a stunning series of proposals.

And – the envelope please – the winners are:

• Sijie Lu, Ph.D., of the M.D. Anderson Cancer Center at the University of Texas in Houston. His research proposal, “Selective Expansion of Anti-Leukemic CTL for Donor Lymphocyte Infusion,” received the ASBMT/Fujisawa New Investigator Award.

• Pavan Reddy, M.D., of the University of Michigan in Ann Arbor. His research proposal, “Role of Antigen Presenting Cells in Mediating Graft-vs-Leukemia Effect after Experimental Allogeneic Bone Marrow Transplantation,” received the ASBMT/ESP Pharma New Investigator Award.

I extend my congratulations, both personally and on behalf of the Society, to these two excellent scientists. I would also like to reiterate my appreciation to both ESP Pharma and Fujisawa for their generous support of these awards.

– Joe

 
Legislation and Regulation
 
Congress passes bill to create National Cord Blood Stem Cell Bank
The U.S. Senate has approved an initial $10 million appropriation to establish a National Cord Blood Stem Cell Bank Network. The goal is to collect, over five years, an inventory of 150,000 cord blood stem cell units. The program is estimated to cost $150 million and will be administered by the Health Resources and Services Administration.
 
House of Lords set to decide on “designer baby” case
Britain’s House of Lords will meet to determine whether it is legal to use tissue type selection, as a couple recently did with an IVF embryo. The couple were granted permission last year by the Human Fertilisation and Embryology Authority to screen the tissue type of their IVF embryos to select one whose stem cells would be genetically compatible to their terminally ill son’s. The mother later suffered a miscarriage.
 
Clinical Research
 
  Chemotherapy and autologous stem cell transplant increases amyloidosis survival rate
Survival rates increased from one year to nearly five years after patients suffering from primary amyloidosis received high-dose chemotherapy and autologous stem cell transplantation, according to a study published in the Jan. 20 issue of the journal Annals of Internal Medicine. Forty percent of the 312 patients studied experienced complete remission after treatment, with half surviving more than 4.5 years and none having relapses after two years.

  Stem cell injections prove effective in treating osteoarthritis in goats
Stem cell injections have been shown to regenerate joint tissues and retard cartilage damage in goats suffering from surgically induced osteoarthritis, according to a report in the December 2003 issue of the journal Arthritis and Rheumatism. Researchers injected stem cells taken from the bone marrow of the goats into the knee and noted marked regeneration of joint tissues, as well as detecting implanted cells in the new tissue.

  Autologous stem cell transplant improves quality of life for patients with refractory juvenile rheumatoid arthritis
Autologous hematopoietic stem cell transplantation appears to be a safe and feasible way to improve quality of life in patients suffering from refractory juvenile rheumatoid arthritis, according to a study published in the December 2003 issue of the International Journal of Hematology. Japanese researchers studied the safety and efficacy of autologous CD34+ stem cell transplantation in three patients ages 3, 13 and 21; two of the patients achieved complete disease remission.
 
  Pharmaceutical News
 
  Stem Cell Preservation Technologies Inc. closing
Clearwater, Fla.-based Cryo-Cell International Inc. is closing its majority-owned subsidiary, Stem Cell Preservation Technologies Inc., following the resignation of Stem Cell’s board of directors and management. Cryo-Cell had rejected a restructuring proposal from Stem Cell’s management that would have required substantial additional funding to continue Stem Cell’s operation.
 
  Association News
 

  ASBMT journal begins Web-based manuscript acceptance
Biology of Blood and Marrow Transplantation is now accepting manuscripts via the Web. Beginning this month, manuscripts and related figures and tables should be submitted electronically through the journal’s Web site. “I believe that authors will find the new system very easy to handle, and it provides us even greater speed in the review process,” said Robert Korngold, Ph.D., editor-in-chief. Complete instructions are available at the Web site.

  Rob Negrin chosen to lead ASBMT in 2006
Robert Negrin, M.D., has been chosen by mail ballot of ASBMT members to be the society’s vice president. The office places him in line to assume the presidency two years from now. Daniel Weisdorf, M.D., was re-elected secretary of the Board of Directors. Newly elected directors are Claudio Anasetti, M.D.; Samuel Silver, M.D., Ph.D.; and Robert Truitt, Ph.D. All will take office at the close of the Tandem BMT Meetings this month in Orlando. 

  New Investigator Award announced for GvL project
The recipient of the ASBMT/ESP Pharma New Investigator Award is Pavan Reddy, M.D., at the University of Michigan for work on the “Role of Antigen Presenting Cells in Mediating Graft-versus-Leukemia Effect After Experimental Allogeneic Bone Marrow Transplantation.” The $25,000-per-year award was announced by ASBMT President Joseph H. Antin. Renewable for a second year, the award is funded by an unrestricted educational grant from ESP Pharma Inc. 

  Tandem BMT Meetings to convene in Hawaii in 2006
Hotel and convention center negotiations have been completed for the 2006 Tandem BMT Meetings that will be held Feb. 15-19 in Honolulu. The meetings will be at the Hawaii Convention Center, with the Ala Moana Hotel across the street as the headquarters hotel. For those wanting to stay on Waikiki Beach, about three blocks from the convention center, guestrooms also will be available at special group rates at the Renaissance Ilikai Waikiki Hotel and the Hilton Hawaiian Village.

  Travel grants announced for Tandem BMT Meetings
The ASBMT Board of Directors has awarded travel grants of $1,000 each to the young investigators invited to give oral presentations at the 2004 Tandem BMT Meetings. This year, 40 of the 66 oral abstracts will be presented by young investigators – those not more than five years past an M.D. or Ph.D. degree.

  New Web site for transplantation genomics
The National Institutes of Health, the National Center for Biotechnology Information and the International Histocompatibility Working Group in Hematopoietic Cell Transplantation have announced the debut of "dbMHC-HCT" -- a Web-based public database to promote collaborative research in the genomics of transplantation. The official launch of the Web site will take place at the Tandem BMT Meetings on Feb. 14 in Orlando. Ongoing demonstrations will be available at the NCBI exhibit booth.
 

 
 
  

Copyright © 2004 American Society for Blood and Marrow Transplantation. All rights reserved.

The editor for ASBMT eNews is Andrew L. Pecora, M.D.

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