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Gene identified that controls development of embryonic nerve cells



Administering myoblasts via catheter proves effective in repairing heart

  
January 5, 2004
  
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Top Stories
   
Legislation and Regulation
   
Clinical Research
   
Pharmaceutical News
   
Association News
   
Calendar
 
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Tandem BMT Meetings
Feb 13 - 17, 2004
Orlando, Florida

 
 
ASBMT Monthly Poll
The Tandem BMT Meetings are traditionally held in February. Would you be interested in convening the meetings on a privately booked cruise ship in the Caribbean?
Yes. I’d like to do this, if the price is right.
I’m not really sure. It would be difficult for participants and speakers who want to attend only a portion of the meetings.
No. Holding the meetings at sea has little appeal to me.
Other (Please fill in "comments" after submitting)

view results

(Note: Answers to this interactive poll are anonymous.)
 

Last Month's Poll Results

How are intensive care patients managed at your transplant center?
Our intensive care patients are treated in our transplant unit. (173) 25%
   
Our intensive care patients are transferred to an ICU, either within the institution or at a nearby hospital. (442) 64% 
   
Other (78) 11%
 

Calendar

January
American Society of Transplantation (AST)
8th Annual Winter Symposium

Jan. 15-18
Westin Kierland Resort
Scottsdale, Ariz.

February
6th International Congress on New Trends in Immunosuppression
Feb. 5-8
Salzburg Congress Centre
Salzburg, Austria

Tandem BMT Meetings
(Combined ASBMT and IBMTR/ABMTR annual meetings)

Feb. 13-17
Coronado Springs Resort
Orlando, Fla.

March
American Association for Cancer Research (AACR)
95th Annual Meeting

March 27-31
Orange County Convention Center
Orlando, Fla.

European Group for Blood and Marrow Transplantation (EBMT)
30th Annual Meeting

March 28 - 31
Palau de Congressos de Catalunya
Barcelona, Spain

April
American Society of Pediatric Hematology/Oncology (ASPH/O)
17th Annual Scientific Meeting

April 29-May 2
Westin St. Francis Hotel
San Francisco

May
International Society for Cellular Therapy (ISCT)
10th Annual Meeting

May 7-10
The Burlington Hotel
Dublin, Ireland

World Marrow Donor Association (WMDA)
5th International Donor Registry Conference

May 26-29
Keio University Mita Campus
Tokyo, Japan

• June
Canadian Blood and Marrow Transplant Group (CBMTG)
Biennial Meeting

June 3-6
London Convention Centre
London, Ontario

American Society for Clinical Oncology (ASCO)
40th Annual Meeting

June 5-8
Ernest N. Morial Convention Center
New Orleans

International Society for Stem Cell Research (ISSCR)
2nd Annual Meeting

June 10-13
Boston Seaport Hotel
Boston

• July
Federation of Clinical Immunology Societies (FOCIS)
4th Annual Conference

July 18-23
Palais de Congres de Montreal
Montreal, Quebec

International Society for Experimental Hematology (ISEH)
33rd Annual Scientific Meeting

July 17-20
New Orleans Marriott
New Orleans

• October
American Society for Histocompatibility and Immunogenetics (ASHI)
30th Annual Meeting

Oct. 1-6
San Antonio Convention Center
San Antonio, Texas

American Association of Blood Banks (AABB)
57th Annual Meeting

Oct. 23-26
Baltimore

American Society of Human Genetics (ASHG)
54th Annual Meeting

Oct. 26-30
Toronto, Canada

2005
Tandem BMT Meetings
(Combined ASBMT and IBMTR/ABMTR annual meetings)

Feb. 10-14
Keystone Resort
Keystone, Colo.

 
  
Top Stories
 
Gene identified that controls development of embryonic nerve cells
Researchers have identified a gene in the cerebral cortex that appears to control the developmental clock of embryonic nerve cells, paving the way for tissue replacement therapy in the central nervous system. By manipulating this gene, scientists at the New York University School of Medicine tricked the brains of embryonic mice into producing cortical cells, according to an article in the Jan. 2 issue of the journal Science.
   
Substance identified to induce dedifferentiation in muscle cells
Scientists at the Scripps Research Institute have identified a synthetic compound – called reversine -- that can induce cells to undergo dedifferentiation, turning adult muscle cells into multipotent precursor cells. The researchers hope this finding will help prompt epimorphic regeneration, similar to how amphibians regenerate lost tails and limbs. The results will be published in an upcoming issue of the Journal of the American Chemical Society.
 
Chemical derived from sea snails stops human embryonic stem cell development
By treating human embryonic stem cells with a substance called BIO, derived from sea snails, scientists at Rockefeller University have stopped the cells from developing into specialized adult cells. BIO activates the Wnt pathway and may eliminate the need for mouse support cells and the associated problems of contaminating proteins.
 
Martin Evans, discoverer of stem cells, receives knighthood
Martin Evans, professor of mammalian genetics at Cardiff University, has been named a Fellow of the Royal Society for his services to medical science. Evans is credited with discovering embryonic stem cells in 1981, and he also created a method to alter genes in mice, among other breakthroughs.
  
 

A Word from President Joseph Antin, M.D.

Have You Voted?

If you are a Member of our society, you should have received a ballot in the mail within the past week or so for choosing ASBMT officers and directors. To my knowledge, few medical societies are as democratic as ours.

In many national associations, the officers and directors are selected by their Board, which tends to be self-perpetuating. Others present a single slate of nominees for office, one candidate per position, so the outcome is virtually decided before the balloting begins. Still others have a house of delegates, which is fine but doesn’t provide for direct participation by the members.

I’ve always been proud that our Society gives members a contest for every open officer and director position. Members have a real say in who will be the leaders of their Society. One of the benefits has been a healthy turnover of leadership and a constant infusion of new ideas and experiences.

If you think your ballot doesn’t count (for instance, if you live in Massachusetts), I can tell you about an election not long ago that was won by a single vote. It was a near miss “constitutional crisis” for our Society because we had no policy on how to break a tie. Since then, the ASBMT Bylaws have been amended to provide a tie-breaking procedure. At the time of the amendment, the Board received several amusing recommendations, including the suggestion of a duel between tied candidates. We can hope that this wit isn’t reflective of the general sense of humor of our members.

The deadline for returning your ballot is Jan. 14. You know what to do.

Conventional Intimacies
Last month in San Diego, as a perennial ASH attendee, I was once again struck by the quality of the work but the inability to see what I wanted to see. Simultaneous sessions are often too simultaneous for me to move back and forth effectively, particularly given the distances between some of the meeting rooms. If you miss a talk, it’s hard to connect with the author to chat about it later.

The posters, too, are often quite interesting, but the sheer numbers and noise makes it difficult to take it all in. Information overload. This is in contrast to our own Tandem BMT Meetings, where time and space do not require Stephen Hawking to set your itinerary. Our more intimate meeting allows us all to digest some of the data and meet to establish collaborations. I encourage everyone to make their travel arrangements early – remembering that Presidents’ weekend coincides with our meeting.

A Cruise Anyone?
Speaking of the Tandem BMT Meetings, what would you think of holding the annual February event on a cruise ship in the Caribbean?

As you probably know, we have a pattern of meeting every second year in Keystone, Colo. In the alternate years we head to a warm climate. The year 2008 will be a non-Keystone year. During our recent Board of Directors meeting, it was suggested that we consider placing the entire meeting on a privately booked cruise ship, sailing perhaps out of Miami or Fort Lauderdale.

There are pros and cons. One of the big concerns is that participants, and speakers, couldn’t come and go as easily. But maybe that is a “pro” as well. We will need to look into the cost of such a venture, of course. Please let us know your thoughts, using the ASBMT Monthly Poll to the left of this column.

On behalf of the Society’s officers and directors, I extend to you and your family our best wishes for a very happy and productive New Year.

– Joe

 
Legislation and Regulation
 
New Jersey assembly passes legislation allowing embryonic stem cell research
The New Jersey State Assembly passed a bill allowing embryonic stem cell research with a vote of 41 to 31, and Gov. Jim McGreevey is expected to sign the bill into law. Passage of the bill, which outlaws cloning, will make New Jersey only the second state to allow such research.
 
Clinical Research
 
  Human embryonic stem cells may cure Parkinson’s disease
Genetically modified human embryonic stem cells can cure Parkinson’s disease in rats, according to a Korean study published in the Dec. 19 issue of the journal Neuroscience Letters. Researchers injected two genes related to generating dopamine into human embryonic stem cells and implanted them into the brains of rats suffering from Parkinson’s disease; normal muscle movement returned six weeks after the procedure.

  Administering myoblasts via catheter proves effective in repairing heart
In five patients suffering heart failure after a heart attack, threading a catheter through a leg artery and into the heart and injecting myoblasts directly into the affected area repaired the damage. In a study published in the Dec. 17 issue of the Journal of the American College of Cardiology, patients showed improvement in heart output at three and six months, as well as significant thickening of the heart wall near the injection site.

  Single antibiotic dose appears best in children undergoing stem cell transplant
As in adults, a single dose of tobramycin in children under age 18 undergoing a stem cell transplant is more effective than the standard three-dose regimen, says a report in the Dec. 17 issue of the Journal of the National Cancer Institute. In the 60 children studied, the single dose also resulted in less damage to the kidneys.

  Mini stem cell transplants provide remission from recurrent mantle cell lymphoma
Mini, non-myeloablative allogeneic stem cell transplants provide sustained remissions in patients suffering from recurrent mantle cell lymphoma, according to the results of a study published in the Dec. 1 issue of the Journal of Clinical Oncology. A clinical trial at the M.D. Anderson Cancer Center in 18 patients showed complete remission in 17 patients and progression-free survival of 82 percent at follow-up an average of more than 26 months later.
 
  Pharmaceutical News
 
  Amgen Inc. buys $20 million stake in ViaCell Inc.
In exchange for a $20 million share, Boston-based ViaCell Inc. will gain licenses to research several of Amgen Inc.’s growth factors. In addition, Amgen will have the option to cooperate in the development of future ViaCell projects.


  Positive results for Velcade bring trials to an early end
Millennium Pharmaceuticals Inc., manufacturer of Velcade (bortezomib), is bringing the control arm of the phase III Apex trial to an early halt, based on the results of an independent data monitoring committee. Because of a significantly significant improvement in time to disease progression in patients receiving Velcade, patients currently receiving dexamethasone can immediately cross over to Velcade.
 
  Association News
 

  Reserve housing by Jan. 12 for Tandem BMT Meetings
The deadline is Jan. 12 for housing for the 2004 Tandem BMT Meetings, Feb. 13-17 in Orlando. After that date, sleeping accommodations at special convention rates are on a “space available” basis. A Housing Reservation Form can be downloaded from the ASBMT Web site, or call Coronado Springs Resort reservations at (407) 939-1020. The special conference rate is $138 for a single or double.

  New Investigator Award will be presented for LDI project
The recipient of the ASBMT/Fujisawa New Investigator Award is Sijie Lu, Ph.D., at M.D. Anderson Cancer Center for work on “Selective Expansion of Anti-Leukemic CTL for Donor Lymphocyte Infusion.” The $25,000-per-year award was announced by ASBMT President Joseph H. Antin. Renewable for a second year, the award is funded by an unrestricted educational grant from Fujisawa Healthcare Inc.

  Travel grants announced for Tandem BMT Meetings
The ASBMT Board of Directors has awarded travel grants of $1,000 each to the young investigators invited to give oral presentations at the 2004 Tandem BMT Meetings. This year, 40 of the 66 oral abstracts will be presented by young investigators – those not more than five years past an M.D. or Ph.D. degree. 

  Free ASBMT membership for trainees
Post-doctoral fellows and physicians-in-training for blood and marrow transplantation are eligible for free ASBMT membership in 2004. The recruitment program has increased in-training enrollments in the Society from 26 to 123 in the past several months.
 

 
 
  

Copyright © 2004 American Society for Blood and Marrow Transplantation. All rights reserved.

The editor for ASBMT eNews is Andrew L. Pecora, M.D.

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