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Retinal cells created from human embryonic stem cells



Treated allogeneic stem cell transplants rebuild liver in mice

  
October 1, 2004
  
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Clinical Research
   
Pharmaceutical News
   
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ASBMT HOME

Tandem BMT Meetings
Feb 10 - 14, 2005
Keystone, Colorado

 
ASBMT and Public Advocacy

How assertive should ASBMT be in areas of public policy? Advise your Society’s leaders through this multiple-choice poll.

(Note: Your answers to this interactive poll are anonymous.)
 

Last Month's Poll Results

Last month readers were asked about policies on the use of nurse practitioners in the transplant center.

Excluding the “don’t know” and “not applicable” responses, 89% said that their transplant center does use nurse practitioners.

Among those using nurse practitioners:
81 percent said nurse practitioners administer pre-medication for pain or anxiety.
43 percent said nurse practitioners administer conscious sedation for bone marrow biopsy.
Calendar

October
American Society for Histocompatibility and Immunogenetics (ASHI)
30th Annual Meeting
Oct. 1-6
San Antonio Convention Center
San Antonio, Texas

4th Annual Conference on Mesenchymal and Nonhematopoietic Stem Cells
American Society for Blood and Marrow Transplantation (ASBMT),
with the International Society for Cellular Therapy (ISCT)
Oct. 14-16
Wyndham Hotel
New Orleans, Louisiana

International Cytokine Society (ICS)
and International Society for Interferon and Cytokine Research (ISICR)

Cytokines in Cancer and Immunity
Oct. 21-25
Caribe Hilton Hotel
San Juan, Puerto Rico

American Association of Blood Banks (AABB)
57th Annual Meeting
Oct. 23-26
Baltimore Convention Center
Baltimore, Maryland

American Society of Human Genetics (ASHG)
54th Annual Meeting
Oct. 26-30
Toronto Convention Centre
Toronto, Ontario

National Marrow Donor Program (NMDP)
17th Annual Council Meeting
Oct. 29-31
Hilton Minneapolis Hotel
Minneapolis, Minnesota

• November
European Society of Gene Therapy (ESGT)
12th Annual Meeting
Nov. 4-7
Tampere Hall Congress Center
Tampere, Finland

• December
American Society of Hematology (ASH)
46th Annual Meeting
Dec. 4-7
San Diego Convention Center San Diego, California

American Society for Cell Biology (ASCB)
44th Annual Meeting
Dec. 4-8
Washington Convention Center
Washington, D.C.

2005
• January
Stem Cell Transplantation in Children: Current Results and Controversies
Alfred I. duPont Hospital for Children and
Cincinnati Children's Hospital Medical Center
Jan. 20-22
DoubleTree La Posada
Scottsdale, Arizona

• February

Tandem BMT Meetings
(Combined ASBMT and CIBMTR annual meetings)
Feb. 10-14
Keystone Conference Center
Keystone, Colorado

• March
American Society of Transplantation (AST)
and Canadian Society of Transplantation (CST)

9th Annual Winter Symposium
March 16-20
Fairmont Banff Springs
Banff, Alberta

European Group for Blood and Marrow Transplantation (EBMT)
31st Annual Meeting
March 20 – 23
Prague Congress Centre
Prague, Czech Republic

• April
American Association for Cancer Research (AACR)
96th Annual Meeting
April 16-20
Anaheim Convention Center
Anaheim, California

• May
International Society for Cellular Therapy (ISCT)
11th Annual Meeting
May 4-7
Vancouver Convention & Exhibition Center
Vancouver, British Columbia

Federation of Clinical Immunology Societies (FOCIS)
5th Annual Conference
May 12-16
Boston, Massachusetts

American Society of Pediatric Hematology/Oncology (ASPH/O)

18th Annual Meeting
May 14-16
Renaissance Washington D.C. Hotel
Washington, D.C.

American Society for Clinical Oncology (ASCO)
41st Annual Meeting
May 14-17
Orlando, Florida

American Society of Transplantation (AST)
American Transplant Congress
May 20-25
Seattle, Washington

2006

Tandem BMT Meetings
(Combined ASBMT and CIBMTR annual meetings)
Feb. 15-19
Hawaii Convention Center
Honolulu, Hawaii

 
  
Top Stories
 
Umbilical matrix is rich source of stem cells
Wharton’s jelly, the material that forms the matrix in the umbilical cord, could provide a potentially inexhaustible source of stem cells, according to researchers at Kansas State University. These cells, called cord matrix stem cells, have been shown to differentiate into multiple cell types.
   

India establishes stem cell research center
The All India Institute of Medical Sciences in New Delhi, India, is setting up a stem cell research center. The facility is designed to help scientists advance basic and applied research in stem cell technologies, as relevant to India’s health needs.

 
Retinal cells created from human embryonic stem cells
Scientists at Advanced Cell Technology in Massachusetts have created retinal cells using human embryonic stem cells. In addition, the cells cluster into small globes, with some cells resembling those that make rods and cones. The creation of the stem cell lines used in this research was funded solely through private donations, circumventing the ban on using federal funds to create new stem cell lines.
     
Spain to allow embryonic stem cell research
Starting at the end of October, Spain will allow embryonic stem cell research, according to the Spanish health minister. Spain plans to have two research centers – one in Catalonia, specializing in regenerative medicine, and a stem cell bank in Granada, which opened in January 2004.
 

A Word from President Armand Keating, M.D.

Glance down at your computer keyboard. Grab onto both ends with your hands to steady yourself. The unheard of is about to be announced.

You are all too familiar with medical societies changing their dues. Invariably it involves an increase.

It’s with great pleasure that I announce that ASBMT dues are being lowered for 2005. (Do lean a little closer to the computer screen so I can see the amazed expression.)

The ASBMT Board of Directors has adopted the following changes for the coming year:
• Dues for Members will be $175 – down from the current $225.
• Dues for Association Members (MDs and PhDs not directly involved in the clinical practice of blood and marrow transplantation or cellular research) will be $175 – down from the current $225.
• Dues for Affiliate Members (allied non-MD and non-PhD professionals and administrators) will be $125 – down from the current $175.
• Dues for In-Training Members will be $75.

Dues were raised in 2001 because of the costs of moving the journal to a monthly publication schedule and other fiscal needs of the Society. You stood by the Society when times were lean. Our membership enrollment actually grew that year. It’s increased by 29 percent since.

Now, when it appears we have made it through that difficult period, the Society’s leaders want to return dues in good faith to the pre-2001 levels.

This doesn’t mean that your Society is awash in cash and fiscal reserves. (If only it were so!) But it does mean that our young organization has reached a plateau of financial stability, in no small part because of the success and growth of our journal, Biology of Blood and Marrow Transplantation, and the annual Tandem BMT Meetings.

Membership dues represent 14 percent of the Society’s total revenues. The majority of ASBMT income is earned on journal and annual meeting revenues and grants from industry.

The dues reduction will “cost” the Society about 2 percent of current revenues. However, the Board is banking on the lower dues spurring recruitment of new members, thereby more than offsetting the foregone income.

Now here’s your part of the bargain. In a few days you’ll be receiving an e-mail about paying 2005 dues online by credit card. If you do that – and respond right away – it will short-circuit the dues statement that otherwise would be mailed to you later in the month. That will save the costs of preparing and mailing the statement and processing payments that are mailed back. And it will assure that there are no reminder notices and no interruption in the copies of your journal come January.

Before damage is done to your keyboard, you can release it now to go recruit your colleagues. Some of them probably are not yet members of this remarkable medical society.

- Cheers, Armand

 
Clinical Research
 
  Mini stem cell transplants may boost cancer survival
A series of mini stem cell transplants, combined with lower doses of chemotherapy, appears to lead to higher survival rates in patients with cancer. Researchers at the M.D. Anderson Cancer Center say survival of lymphoma patients receiving this treatment is 80 percent, compared to 40 to 50 percent with patients undergoing standard chemotherapy.

  Treated allogeneic stem cell transplants rebuild liver in mice
Liver progenitor cells removed from mice, treated with a healthy human gene and returned to the mice, begin to rebuild the liver with cells that express the human gene, according to a study published in the online issue of the journal Hepatology. Researchers at the University of Florida used green fluorescent protein to mark the donor cells, and 18 weeks after transplantation, 40 to 50 percent of the regenerated liver contained this protein.


  Human umbilical cord blood cells successfully treat strokes in rats
Treating rats suffering from induced strokes with human umbilical cord blood cells reveals that, the larger the dose of cells, the smaller the volume of damage to the brain, according to a report published in the October issue of the journal Stroke. Researchers from the University of South Florida also discovered that the human cells were located only in the injured brain hemisphere and the spleen.


  Cells may prove to be natural heart pacemakers
In a bid to replace electronic pacemakers, Israeli researchers coaxed human embryonic stem cells to differentiate into standard heart muscle cells and injected them into the hearts of pigs with abnormally slow heart rates. In 11 of 13 pigs, the injected cells produced their own heart rhythm.
 
Pharmaceutical News
 
  Patent application filed for human pancreatic beta islets development method
Vitro Diagnostics Inc., in Aurora, Colo., has filed a patent application with the United States Patent and Trademark Office to cover its method for growing and differentiating human pancreatic beta islets. The company developed an invitro model system of human stem cells that can be induced to form beta islets that produce and secrete insulin in response to elevated glucose stimulation. 
   
  Association News
 

  Dues will be lower for ASBMT members in 2005
A reduction in dues has been announced by the ASBMT Board of Directors. Member dues will be $175 -- down from the current $225. There will be similar reductions in Associate Member and Affiliate Member categories.  

  Continued growth of ASBMT programs expected next year
At the same time that dues are being reduced, ASBMT will expand programs that further the Society’s mission to support stem cell research, scholarly publication, physician education and clinical practice. 

  Registration is open for 2005 Tandem BMT Meetings
Go online for early registration rates for the 2005 Tandem BMT Meetings, Feb. 10-14 at Keystone Conference Center in Keystone, Colo. The early registration deadline is Oct. 18. 

  Tandem BMT Meetings abstract deadline is Oct. 18
The deadline for online submission of abstracts for the 2005 Tandem BMT Meetings is Oct. 18. Scientific program time slots have been set aside for oral presentation of about 60 accepted abstracts, as determined by the Abstract Review Committees. Additional abstracts will be presented in two poster sessions.

  40 travel grants available for 2005 Tandem BMT Meetings
The ASBMT Executive Committee has announced 40 travel grants of $1,000 each for young investigators (not more than five years in the BMT field) submitting abstracts to the 2005 Tandem BMT Meetings in February.

  Free ASBMT membership for trainees
Postdoctoral fellows and physicians-in-training for blood and marrow transplantation are eligible for free membership in the American Society for Blood and Marrow Transplantation. During the months of October and November, annual dues will be waived for new trainees who apply for membership in the Society.

  BBMT features review on steroid-resistant GvHD
This month’s issue of Biology of Blood and Marrow Transplantation presents a review of GvHD therapies. “Novel Approaches to the Therapy of Steroid-Resistant Graft-versus-Host Disease” is authored by Drs. Joseph Antin, Allen Chen, Daniel Couriel, Vincent Ho, Richard Nash and Daniel Weisdorf. Also in the October issue is a conference summary and abstracts from the Second Annual International Umbilical Cord Blood Symposium held this past May in Los Angeles. 

  Autoimmune diseases: When homeland security fails
Autoimmune diseases can be viewed as an insurrection by security forces charged with protecting us from lurking outside dangers. Although treatments for human autoimmune disease generally have been disappointing, investigators are beginning to compile an impressive array of early clinical data suggesting a potentially important role for hematopoietic cell transplantation. These advances are reviewed in the current issue of Blood and Marrow Transplantation Reviews.  

  4th Mesenchymal and Nonhematopoietic Stem Cells Conference this month
The annual conference on mesenchymal stem cell biology, stem cell plasticity and cell therapy for cardiac, pulmonary and neurologic diseases will be Oct. 14-15, in New Orleans. ASBMT is a co-sponsor.  


  Transplants vs. low-dose therapy in NHL is topic of online CME program
Dr. James Armitage presents recent data on non-Hodgkin’s lymphoma, focusing on clinical evidence that compares the outcomes of hematopoietic cell transplant to other therapies. The online program provides information on patient selection, expected outcomes of autologous and allogeneic transplantation, and the pros and cons of each choice in comparison to other therapies.   

  Cord blood registry expands by three banks
The National Marrow Donor Program (NMDP) has added three new cord blood member banks, increasing the number of units on its public cord blood registry by more than 20 percent.  

  Deadline for Stem Cell Research Foundation grants is Oct. 19
Grant awards of up to $50,000 per year for two years are available from the Stem Cell Research Foundation. The application deadline is Oct. 19.   

  ASBMT Monthly Poll: ASBMT and Public Advocacy
How assertive should ASBMT be in areas of public policy? Advise your Society’s leaders through this multiple-choice poll.    
vote here...

 
 
  

Copyright © 2004 American Society for Blood and Marrow Transplantation. All rights reserved.

The editor for ASBMT eNews is Andrew L. Pecora, M.D.

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