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July 5, 2005 |
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Top
Stories |
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Legislation and Regulation |
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Clinical
Research |
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Pharmaceutical News |
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Association
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Calendar |
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Job &
Fellowship Connections |
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Monthly Journal |
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eNews
Archives |
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BMT Tandem
Meetings
Feb. 16-20, 2006
Honolulu, Hawaii |
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Too many in the general public
confuse stem cell transplantation with research involving human
embryonic stem cells. What steps should ASBMT take? |
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Last Month's Poll Results |
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Are you finding it more or less
difficult to participate in clinical trials?
42% – More
difficult than in the past.
17% – About the same. No significant difference
17% – Not as difficult
25% – I’m not involved in clinical trials
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Calendar |
• July
Pan-Pacific Lymphoma Conference
University of Nebraska Medical Center
July 11-15
Hyatt Regency Kauai
Poipu, Hawaii
Society for Cryobiology
Cryo 2005, 42nd Meeting
July 24-27
University of Minnesota
Minneapolis, Minnesota
Aplastic Anemia & MDS International Foundation (AA&MDSIF)
Patient & Family Conference
July 28-30
Denver Airport Marriott
Aurora, Colorado
International Society for Experimental Hematology (ISEH)
34th Annual Scientific Meeting
July 30-Aug. 2
Glasgow, Scotland
• September
Targeted and Tailored Therapies in Hematology/Oncology
Loyala University Health System
Sept. 10
Renaissance Chicago Hotel
Chicago, Illinois
8th Biennial Oncology, Hematology and Stem Cell
Transplantation Conference
Alta Bates Comprehensive Cancer Center
Sept. 15-18
The Ritz-Carlton
Half Moon Bay, California
• October
American Association of Blood Banks (AABB)
58th Annual Meeting
Oct. 15-18
Seattle Convention Center
Seattle, Washington
Aplastic Anemia & MDS International Foundation
with NCI and NIH Office of Rare Diseases
Bone Marrow Failure Scientific Symposium
Oct. 17-19
Loews L’Enfant Plaza Hotel
Washington, D.C.
American Society for Histocompatibility and Immunogenetics (ASHI)
31st Annual Meeting
Oct. 17-21
Hilton Washington Hotel
Washington, D.C.
International Society for Interferon and Cytokine Research (ISICR)
Annual Meeting
Oct. 20-24
Shanghai International Everbright Convention Center
Shanghai, China
International Cytokine Society (ICS)
Annual International Cytokine Conference
Oct. 27-31
Lotte Hotel Jamsil
Seoul, Korea
European Society of Gene Therapy (ESGT)
13th Annual Meeting
Oct. 29-Nov. 1
Hotel Hilton Prague
Prague, Czech Republic
• November
National Marrow Donor Program (NMDP)
18th Annual Council Meeting
Nov. 4-6
Hilton Minneapolis Hotel
Minneapolis, Minnesota
• December
American Society of Hematology (ASH)
76th Annual Meeting
Dec. 3-6
Ernest N. Morial Convention Center
New Orleans, Louisiana
American Society for Cell Biology (ASCB)
45th Annual Meeting
Dec. 10-14
Moscone Center
San Francisco, California
2006
BMT Tandem Meetings
(Combined ASBMT and CIBMTR annual meetings)
Feb. 16-20
Hawaii Convention Center
Honolulu, Hawaii
2007
BMT Tandem Meetings
(Combined ASBMT and CIBMTR annual meetings)
Feb. 8-12
Keystone Conference Center
Keystone, Colorado
2008
BMT Tandem Meetings
(Combined ASBMT and CIBMTR annual meetings)
Feb. 13-17
Manchester Grand Hyatt Hotel
San Diego, California
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Top
Stories |
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Unlimited quantity of mesenchymal precursor cells derived from
embryonic cells
Using new techniques in the laboratory, researchers at
Memorial Sloan-Kettering Cancer Center have derived unlimited
numbers of purified mesenchymal precursor cells from human
embryonic stem cells. Researchers took two lines of
undifferentiated cells and stimulated them to turn into
mesenchymal cells, then treated these cells with compounds to
make them change into specialized bone, cartilage, fat and
muscle cells.
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Even very low doses of radiation pose cancer
risk
Radiation doses as small as those in common X-rays pose a
risk of cancer over a person’s lifetime, according to a report
released by a panel of the National Academy of Sciences. The
panel said there appears to be no threshold of exposure below
which cancers are not induced and estimated that about one
person in 1,000 would develop cancer from exposure to the amount
of radiation from a single, average whole-body CT scan.  |
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Blacks, other minorities face greater risk of colorectal cancer
Blacks and other minorities in the United States face as
much as a 60 percent greater risk of colorectal cancer at an
advanced stage than do whites, according to a study that will
appear in the Aug. 1 issue of the journal Cancer. Minorities are
up to 30 percent more likely to die from the disease, according
to data on more than 150,000 people from 18 different races and
ethnicities who were diagnosed with colorectal cancer from 1988
to 2000.  |
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California university receives $40 million
to fund research center
The University of California at Berkeley has received a $40
million donation from Hong Kong billionaire Ling Ka-shing’s
charitable foundation to fund a center to study stem cell and
brain imaging technology. The $160 million Ling Ka-shing Center
for Biomedical and Health Sciences, to be completed in 2009,
will research cancer, brain diseases, infectious diseases and
stem cell biology.
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A
Word from President Nelson Chao, M.D.
The year was 1950, and it was the Democratic senatorial
primary in Florida. Rep. George Smathers was challenging
Sen. Claude Pepper.
Smathers, the underdog, traveling the rural towns of his
state, accused Pepper of unspeakable indecencies:
• that his brother was a practicing homo sapien
• that he had a sister in New York who was a thespian
• that Pepper himself, while in college, had
matriculated with young women
The story is an amusing example of word trickery,
calculated to pander to the less-educated. But what
happens when the victim of tricky words turns out to
be well-educated, and the potential consequences are
anything but amusing? We had such an incident a few
weeks ago.
A courier was bringing stems cells from a donor in
Europe, headed for a waiting patient at a transplant
center in the United States. The travel was on
commercial airlines on regularly scheduled flights.
Because there were no direct flights, a plane change was
required once the courier touched down in the United
States.
After boarding the jet for the final leg of his journey,
the courier was informed that he would have to leave the
plane. Pilots have the final word on who and what is
carried on their planes, and this particular pilot had a
strong moral aversion to embryonic stem cell research.
After checking the courier’s paperwork, the pilot asked
the courier to get off the plane.
Fortunately, there was a next flight in four hours, and
the courier was able to complete his trip and deliver
the precious package. Potential tragedy averted.
The airline, the pilot and all involved have
subsequently profusely apologized for the terrible
misunderstanding, so it serves no useful purpose to
embarrass people and companies by naming names. In a
sense, the victim may have been the pilot, hammered by
several years of rhetoric about the “stem cell
controversy.”
How many times have we read newspaper headlines and
heard broadcasts reporting on “stem cell legislation”
and developments in the “stem cell debate?” How
frequently in the course of an introduction or mention
of your work has the conversation immediately turned to
embryonic stem cell research? “You work with stem cells?
That’s been getting quite a lot of controversial
attention these days, hasn’t it?”
I learned last week of one colleague whose budget was
challenged when a university board member heard that her
department was working with stem cells. NPR last week
reported threats on the life of a scientist who was
working with stem cells. Sounds like a disaster waiting
to happen when some zealot decides that the world would
be better off with one fewer stem cell transplant
clinician or investigator.
Most of us have well-formed opinions about human
embryonic stem cell research. A while back, ASBMT
leaders placed the Society on record supporting federal
funding for embryonic stem cell research. Yet it is
important for us to recognize that opinions do vary
among earnest, well-educated and well-intentioned
people. Regardless of our personal beliefs, I think we
all can agree on the importance of clarifying for the
public the difference between the theoretic future
benefits of laboratory research with embryonic stem
cells and the very real clinical benefits today of stem
cell transplantation.
Does ASBMT have a role to play in achieving clarity?
Here are some possibilities:
• We could encourage the media to stop the
indiscriminate use of terms like “stem cell research”
and the “stem cell controversy” when reporting on
investigations with human embryos.
• We could revise our own terminology and use phrases
other than “stem cell transplants” to describe what we
do.
• We could work to raise public awareness about what
stem cell transplants achieve and what we clinicians and
investigators study and do.
Any of these would be a daunting task. You may have an
opinion about which is the most doable.
Of course, there is another path. We could decide that
the problem is too large for us to have any impact. We
could do nothing, and resign ourselves to ongoing public
confusion and misunderstanding.
– Nelson |
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Legislation and Regulation |
Senate panel approves umbilical cord blood bill
The Senate Health, Education, Labor and Pensions Committee
has approved by a voice vote a bill (S 1317) that would
establish a national network to expand access to umbilical cord
blood for stem cell research. The bill would allocate $34
million in federal funding for the collection and storage of
umbilical cord blood in fiscal year 2006 and $38 million
annually from FY 2007 to FY 2010. A similar bill in the House
(HR 2520) was passed by a vote of 430 to 1 in May.
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Clinical Research |
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Three-pronged approach to prostate cancer therapy improves
survival
Treating locally advanced prostate cancer with a
three-pronged approach -- testosterone-blocking drugs,
brachytherapy and external beam radiation therapy -- can achieve
a high level of tumor control. According to a report published
in the June issue of the journal Urology, 93 high- and
intermediate-risk patients receiving this therapy had four-year
event-free survival of 79 and 85 percent, respectively. 
Researchers overcome cardiac arrhythmias caused by stem
cell therapy
By using gene therapy to replace a key protein called
connexin 43, researchers at Johns Hopkins University School of
Medicine have minimized arrhythmias resulting from the use of
stem cell therapy to regrow damaged cardiac tissue. According to
a report published in the June 23 online edition of the journal
Circulation Research, this protein makes up the gap
junctions between heart muscle cells, allowing the cells to
communicate and regularly expand and contract.

Oral medication as effective as intravenous in treating
colon cancer
Oral capecitabine slightly improves the chances of
relapse-free survival for people with advanced colon cancer,
according to a study published in the June 30 issue of the
New England Journal of Medicine. Researchers found that
capecitabine is at least as effective as fluorouracil and
leucovorin administered intravenously and is better tolerated,
causing less diarrhea and nausea and leaving patients less
susceptible to infection.

Peptide identified that guides neurons to specific areas of
the brain
The identification of the role of prokinectin 2, a small
peptide, in proper functional integration of new neurons into
brain tissue holds promise for using stem cell therapy to target
specific brain regions affected by neurodegenerative diseases or
stroke. According to a study published in the June 24 issue of
the journal Science, researchers discovered how PK2
guides the migration of neurons born from neural stem cells from
the subventricular zone in the brain's core through mature
tissue to reach the olfactory bulb.
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Pharmaceutical News |
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Association
News |
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Consensus conference considers chronic GvHD
Standards for the diagnosis and evaluation of chronic GvHD and
the need for common nomenclature to communicate about the
disease were principal concerns at an NIH Consensus Conference
on Clinical Trials for cGvHD on June 6 in Bethesda, Md. Public
comment is welcome through Aug. 5 for the working papers that
will be published in BBMT.
Abstracts acceptance begins for BMT Tandem Meetings in
Honolulu
Online abstract submission is open for investigators who
want a head start on preparations for the 2006 BMT Tandem
Meetings, Feb. 16-20 in Honolulu. The deadline for abstracts is
Oct. 3. Online meeting registration and housing will open later
this month.

CD presents all Keystone plenary and concurrent sessions
All plenary and concurrent scientific sessions of the 2005
BMT Tandem Meetings last February in Keystone are included on a
CD that has been mailed to all meeting registrants and to ASBMT members and transplant center medical directors. Nearly 25
hours of presentations are included on the CD that is supported
by a grant from Roche Laboratories. Additional copies of the CD
are available by request.

Meeting with FDA addresses facility compliance issues
Representatives of ASBMT and other organizations in
allogeneic transplantation, gene therapy, tissue banking,
apheresis and biotechnology met with the FDA Center for
Biologics Evaluation and Research (CBER) on June 24 in Bethesda,
Md. The focus of the meeting was prevention of product
contamination in cell processing facilities, but also ranged
across other issues of cellular therapy regulations.
BBMT gets new “impact factor”
Biology of Blood and Marrow Transplantation has earned an ISI Impact Factor of 3.278 -- its highest since the journal was
founded in 1995. BBMT is 4th among 19 transplant journals.

Journal reports on assay for human hematopoietic stem cells
Observations presented in this month’s Biology of Blood and
Marrow Transplantation suggest that cells containing a low level
of rhodamine 123 are highly enriched for primitive hematopoietic
stem cells. Conditioned nonobese diabetic recombination
activating gene-null perforin-null newborn mice are a desirable
model for an assay of long-term transplantable human
hematopoietic stem cells, according to a team led by Dr. Hitoshi
Minamiguchi of the Department of Veterans Affairs Medical Center
at the Medical University of South Carolina.

Novel therapies presented for myelodysplastic syndrome
“Progress has been made in our understanding of the
pathogenesis of the myelodysplastic syndromes, and these
insights are leading to new therapeutic approaches,” said John
Wingard, M.D., in an introduction to the current issue of Blood
and Marrow Transplantation Reviews. The issue, mailed to 10,500
hematologists and oncologists including all ASBMT members,
presents an edited transcript of a symposium held during the
2005 BMT Tandem Meetings in Keystone, Colo. 
CME audioconference offers update on CML therapies
Jane Apperley, M.D., Hammersmith Hospital, London, England,
will provide practical recommendations for deciding how to
assess and treat chronic-phase CML, including case studies and
treatment algorithms, in a live CME audioconference on July 20.
The program is sponsored by the National Marrow Donor Program (NMDP),
the Center for International Blood and Marrow Transplant
Research (CIBMTR) and the Medical College of Wisconsin.

ASBMT monthly poll: Public confusion about stem cells
Many in the general public tend to confuse stem cell
transplantation and research involving human embryonic stem
cells. Take this month’s multiple-choice poll to advise your
Society leaders on how ASBMT should approach this problem.
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