. 

 


Even very low doses of radiation pose cancer risk 


Researchers overcome cardiac arrhythmias caused by stem cell therapy
 
  
July 5, 2005
  
If you are unable to view these articles or access the links, please visit the ASBMT Web Site at www.asbmt.org to read this issue. To be removed from this distribution list, please see instructions at bottom.
 
Top Stories
   
Legislation and Regulation
   
Clinical Research
   
Pharmaceutical News
   
Association News
   
Calendar
   
Job & Fellowship Connections
    
Monthly Journal
   
 eNews Archives
Members:
update email  here
  
 Non-members:
 subscribe here

ASBMT HOME

 BMT Tandem Meetings
Feb. 16-20, 2006
Honolulu, Hawaii


Too many in the general public confuse stem cell transplantation with research involving human embryonic stem cells. What steps should ASBMT take?

Last Month's Poll Results

Are you finding it more or less difficult to participate in clinical trials?

42% – More difficult than in the past.
17% – About the same. No significant difference
17% – Not as difficult
25% – I’m not involved in clinical trials

 

 
Calendar
• July
Pan-Pacific Lymphoma Conference
University of Nebraska Medical Center
July 11-15
Hyatt Regency Kauai
Poipu, Hawaii

Society for Cryobiology
Cryo 2005, 42nd Meeting
July 24-27
University of Minnesota
Minneapolis, Minnesota

Aplastic Anemia & MDS International Foundation (AA&MDSIF)
Patient & Family Conference
July 28-30
Denver Airport Marriott
Aurora, Colorado

International Society for Experimental Hematology (ISEH)
34th Annual Scientific Meeting
July 30-Aug. 2
Glasgow, Scotland

• September
Targeted and Tailored Therapies in Hematology/Oncology
Loyala University Health System
Sept. 10
Renaissance Chicago Hotel
Chicago, Illinois

8th Biennial Oncology, Hematology and Stem Cell Transplantation Conference
Alta Bates Comprehensive Cancer Center
Sept. 15-18
The Ritz-Carlton
Half Moon Bay, California

• October
American Association of Blood Banks (AABB)
58th Annual Meeting
Oct. 15-18
Seattle Convention Center
Seattle, Washington

Aplastic Anemia & MDS International Foundation
with NCI and NIH Office of Rare Diseases

Bone Marrow Failure Scientific Symposium
Oct. 17-19
Loews L’Enfant Plaza Hotel
Washington, D.C.

American Society for Histocompatibility and Immunogenetics (ASHI)
31st Annual Meeting
Oct. 17-21
Hilton Washington Hotel
Washington, D.C.

International Society for Interferon and Cytokine Research (ISICR)
Annual Meeting
Oct. 20-24
Shanghai International Everbright Convention Center
Shanghai, China

International Cytokine Society (ICS)
Annual International Cytokine Conference
Oct. 27-31
Lotte Hotel Jamsil
Seoul, Korea

European Society of Gene Therapy (ESGT)
13th Annual Meeting
Oct. 29-Nov. 1
Hotel Hilton Prague
Prague, Czech Republic

• November
National Marrow Donor Program (NMDP)
18th Annual Council Meeting
Nov. 4-6
Hilton Minneapolis Hotel
Minneapolis, Minnesota

• December
American Society of Hematology (ASH)
76th Annual Meeting
Dec. 3-6
Ernest N. Morial Convention Center
New Orleans, Louisiana

American Society for Cell Biology (ASCB)
45th Annual Meeting
Dec. 10-14
Moscone Center
San Francisco, California

2006
BMT Tandem Meetings
(Combined ASBMT and CIBMTR annual meetings)
Feb. 16-20
Hawaii Convention Center
Honolulu, Hawaii

2007

BMT Tandem Meetings
(Combined ASBMT and CIBMTR annual meetings)
Feb. 8-12
Keystone Conference Center
Keystone, Colorado

2008
BMT Tandem Meetings
(Combined ASBMT and CIBMTR annual meetings)
Feb. 13-17
Manchester Grand Hyatt Hotel
San Diego, California

 
  
Top Stories
 
Unlimited quantity of mesenchymal precursor cells derived from embryonic cells
Using new techniques in the laboratory, researchers at Memorial Sloan-Kettering Cancer Center have derived unlimited numbers of purified mesenchymal precursor cells from human embryonic stem cells. Researchers took two lines of undifferentiated cells and stimulated them to turn into mesenchymal cells, then treated these cells with compounds to make them change into specialized bone, cartilage, fat and muscle cells.
   

Even very low doses of radiation pose cancer risk
Radiation doses as small as those in common X-rays pose a risk of cancer over a person’s lifetime, according to a report released by a panel of the National Academy of Sciences. The panel said there appears to be no threshold of exposure below which cancers are not induced and estimated that about one person in 1,000 would develop cancer from exposure to the amount of radiation from a single, average whole-body CT scan.
 

 
Blacks, other minorities face greater risk of colorectal cancer
Blacks and other minorities in the United States face as much as a 60 percent greater risk of colorectal cancer at an advanced stage than do whites, according to a study that will appear in the Aug. 1 issue of the journal Cancer. Minorities are up to 30 percent more likely to die from the disease, according to data on more than 150,000 people from 18 different races and ethnicities who were diagnosed with colorectal cancer from 1988 to 2000. 
     
California university receives $40 million to fund research center
The University of California at Berkeley has received a $40 million donation from Hong Kong billionaire Ling Ka-shing’s charitable foundation to fund a center to study stem cell and brain imaging technology. The $160 million Ling Ka-shing Center for Biomedical and Health Sciences, to be completed in 2009, will research cancer, brain diseases, infectious diseases and stem cell biology.
 

A Word from President Nelson Chao, M.D.

The year was 1950, and it was the Democratic senatorial primary in Florida. Rep. George Smathers was challenging Sen. Claude Pepper.

Smathers, the underdog, traveling the rural towns of his state, accused Pepper of unspeakable indecencies:
• that his brother was a practicing homo sapien
• that he had a sister in New York who was a thespian
• that Pepper himself, while in college, had matriculated with young women

The story is an amusing example of word trickery, calculated to pander to the less-educated. But what happens when the victim of tricky words turns out to be well-educated, and the potential consequences are anything but amusing? We had such an incident a few weeks ago.

A courier was bringing stems cells from a donor in Europe, headed for a waiting patient at a transplant center in the United States. The travel was on commercial airlines on regularly scheduled flights. Because there were no direct flights, a plane change was required once the courier touched down in the United States.

After boarding the jet for the final leg of his journey, the courier was informed that he would have to leave the plane. Pilots have the final word on who and what is carried on their planes, and this particular pilot had a strong moral aversion to embryonic stem cell research. After checking the courier’s paperwork, the pilot asked the courier to get off the plane.

Fortunately, there was a next flight in four hours, and the courier was able to complete his trip and deliver the precious package. Potential tragedy averted.

The airline, the pilot and all involved have subsequently profusely apologized for the terrible misunderstanding, so it serves no useful purpose to embarrass people and companies by naming names. In a sense, the victim may have been the pilot, hammered by several years of rhetoric about the “stem cell controversy.”

How many times have we read newspaper headlines and heard broadcasts reporting on “stem cell legislation” and developments in the “stem cell debate?” How frequently in the course of an introduction or mention of your work has the conversation immediately turned to embryonic stem cell research? “You work with stem cells? That’s been getting quite a lot of controversial attention these days, hasn’t it?”

I learned last week of one colleague whose budget was challenged when a university board member heard that her department was working with stem cells. NPR last week reported threats on the life of a scientist who was working with stem cells. Sounds like a disaster waiting to happen when some zealot decides that the world would be better off with one fewer stem cell transplant clinician or investigator.

Most of us have well-formed opinions about human embryonic stem cell research. A while back, ASBMT leaders placed the Society on record supporting federal funding for embryonic stem cell research. Yet it is important for us to recognize that opinions do vary among earnest, well-educated and well-intentioned people. Regardless of our personal beliefs, I think we all can agree on the importance of clarifying for the public the difference between the theoretic future benefits of laboratory research with embryonic stem cells and the very real clinical benefits today of stem cell transplantation.

Does ASBMT have a role to play in achieving clarity? Here are some possibilities:

• We could encourage the media to stop the indiscriminate use of terms like “stem cell research” and the “stem cell controversy” when reporting on investigations with human embryos.

• We could revise our own terminology and use phrases other than “stem cell transplants” to describe what we do.

• We could work to raise public awareness about what stem cell transplants achieve and what we clinicians and investigators study and do.

Any of these would be a daunting task. You may have an opinion about which is the most doable.

Of course, there is another path. We could decide that the problem is too large for us to have any impact. We could do nothing, and resign ourselves to ongoing public confusion and misunderstanding.

– Nelson

 
Legislation and Regulation
  Senate panel approves umbilical cord blood bill
The Senate Health, Education, Labor and Pensions Committee has approved by a voice vote a bill (S 1317) that would establish a national network to expand access to umbilical cord blood for stem cell research. The bill would allocate $34 million in federal funding for the collection and storage of umbilical cord blood in fiscal year 2006 and $38 million annually from FY 2007 to FY 2010. A similar bill in the House (HR 2520) was passed by a vote of 430 to 1 in May.

Clinical Research
 
  Three-pronged approach to prostate cancer therapy improves survival
Treating locally advanced prostate cancer with a three-pronged approach -- testosterone-blocking drugs, brachytherapy and external beam radiation therapy -- can achieve a high level of tumor control. According to a report published in the June issue of the journal Urology, 93 high- and intermediate-risk patients receiving this therapy had four-year event-free survival of 79 and 85 percent, respectively. 

  Researchers overcome cardiac arrhythmias caused by stem cell therapy
By using gene therapy to replace a key protein called connexin 43, researchers at Johns Hopkins University School of Medicine have minimized arrhythmias resulting from the use of stem cell therapy to regrow damaged cardiac tissue. According to a report published in the June 23 online edition of the journal Circulation Research, this protein makes up the gap junctions between heart muscle cells, allowing the cells to communicate and regularly expand and contract.

  Oral medication as effective as intravenous in treating colon cancer
Oral capecitabine slightly improves the chances of relapse-free survival for people with advanced colon cancer, according to a study published in the June 30 issue of the New England Journal of Medicine. Researchers found that capecitabine is at least as effective as fluorouracil and leucovorin administered intravenously and is better tolerated, causing less diarrhea and nausea and leaving patients less susceptible to infection. 

  Peptide identified that guides neurons to specific areas of the brain
The identification of the role of prokinectin 2, a small peptide, in proper functional integration of new neurons into brain tissue holds promise for using stem cell therapy to target specific brain regions affected by neurodegenerative diseases or stroke. According to a study published in the June 24 issue of the journal Science, researchers discovered how PK2 guides the migration of neurons born from neural stem cells from the subventricular zone in the brain's core through mature tissue to reach the olfactory bulb.

 
Pharmaceutical News
 
Association News

  Consensus conference considers chronic GvHD
Standards for the diagnosis and evaluation of chronic GvHD and the need for common nomenclature to communicate about the disease were principal concerns at an NIH Consensus Conference on Clinical Trials for cGvHD on June 6 in Bethesda, Md. Public comment is welcome through Aug. 5 for the working papers that will be published in BBMT.

Abstracts acceptance begins for BMT Tandem Meetings in Honolulu
Online abstract submission is open for investigators who want a head start on preparations for the 2006 BMT Tandem Meetings, Feb. 16-20 in Honolulu. The deadline for abstracts is Oct. 3. Online meeting registration and housing will open later this month.

CD presents all Keystone plenary and concurrent sessions
All plenary and concurrent scientific sessions of the 2005 BMT Tandem Meetings last February in Keystone are included on a CD that has been mailed to all meeting registrants and to ASBMT members and transplant center medical directors. Nearly 25 hours of presentations are included on the CD that is supported by a grant from Roche Laboratories. Additional copies of the CD are available by request.

Meeting with FDA addresses facility compliance issues
Representatives of ASBMT and other organizations in allogeneic transplantation, gene therapy, tissue banking, apheresis and biotechnology met with the FDA Center for Biologics Evaluation and Research (CBER) on June 24 in Bethesda, Md. The focus of the meeting was prevention of product contamination in cell processing facilities, but also ranged across other issues of cellular therapy regulations.

BBMT gets new “impact factor”
Biology of Blood and Marrow Transplantation has earned an ISI Impact Factor of 3.278 -- its highest since the journal was founded in 1995. BBMT is 4th among 19 transplant journals.

Journal reports on assay for human hematopoietic stem cells
Observations presented in this month’s Biology of Blood and Marrow Transplantation suggest that cells containing a low level of rhodamine 123 are highly enriched for primitive hematopoietic stem cells. Conditioned nonobese diabetic recombination activating gene-null perforin-null newborn mice are a desirable model for an assay of long-term transplantable human hematopoietic stem cells, according to a team led by Dr. Hitoshi Minamiguchi of the Department of Veterans Affairs Medical Center at the Medical University of South Carolina.

Novel therapies presented for myelodysplastic syndrome
“Progress has been made in our understanding of the pathogenesis of the myelodysplastic syndromes, and these insights are leading to new therapeutic approaches,” said John Wingard, M.D., in an introduction to the current issue of Blood and Marrow Transplantation Reviews. The issue, mailed to 10,500 hematologists and oncologists including all ASBMT members, presents an edited transcript of a symposium held during the 2005 BMT Tandem Meetings in Keystone, Colo. 

CME audioconference offers update on CML therapies
Jane Apperley, M.D., Hammersmith Hospital, London, England, will provide practical recommendations for deciding how to assess and treat chronic-phase CML, including case studies and treatment algorithms, in a live CME audioconference on July 20. The program is sponsored by the National Marrow Donor Program (NMDP), the Center for International Blood and Marrow Transplant Research (CIBMTR) and the Medical College of Wisconsin.
  
ASBMT monthly poll: Public confusion about stem cells
Many in the general public tend to confuse stem cell transplantation and research involving human embryonic stem cells. Take this month’s multiple-choice poll to advise your Society leaders on how ASBMT should approach this problem.

  

Copyright © 2005 American Society for Blood and Marrow Transplantation. All rights reserved.

The editor for ASBMT eNews is Andrew L. Pecora, M.D.

E-newsletter services provided by the medical editors at Ascend Media.

Do you have news, responses or opinions to share with us? Please e-mail the association office at enews@asbmt.org
  

ASBMT eNews is sent as a membership benefit of the American Society for Blood and Marrow Transplantation. If you would prefer not to receive future issues and want to remove your name from our mailing list, please -click here-
 

 
Sponsored by an unrestricted educational grant from