. 

 


Researchers develop
intestine from induced
pluripotent stem cells
 


Stem cells in
microbubbles improve
blood vessel building
  
April 1, 2010
  
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Top Stories
   
Clinical Research
   
Association News
 
BMT Tandem Meetings
 
Calendar
   
Job & Fellowship Connections
    
Monthly Journal
   
eNews Archives
 
 

 

 
  

Best Practices

Should there be uniform rules governing unrelated donor compensation?
 
 
  
Calendar

• April
American Society of Pediatric Hematology/Oncology (ASPH/O)
23rd Annual Meeting
April 7-10
Fairmont Queen Elizabeth Hotel
Montreal, Quebec, Canada

Acute Leukemia Forum 2010 Advances and Controversies in the Biology and Therapy of Acute Leukemia and Myelodysplasia
Hemedicus Acute Leukemia Forum
April 9
Parc 55
San Francisco, California

American Association for Cancer Research (AACR)
101st Annual Meeting
April 17-21
Washington Convention Center
Washington, D.C.

Bioprocessing and Barriers to Clinical Applications of Stem Cell Therapies
5th Annual Wisconsin Stem Cell Symposium
April 21
BioPharmaceutical Technology Center
Madison, Wisconsin

John Theurer Cancer Center at Hackensack University Medical Center
Current and Innovative Modalities in the Management of Hematologic Malignancies
April 23
The Hekemian Conference Center Auditorium
Hackensack, New Jersey

• May
American Transplant Congress
American Society of Transplantation (AST)
May 1-5
San Diego Convention Center
San Diego, California

Immunology 2010
American Association of Immunologists (AAI)
May 7-11
Baltimore Convention Center
Baltimore, Maryland

14th Annual International Congress of Hematologic Malignancies: Focus on Leukemias, Lymphomas and Myelomas
Physicians’ Education Resource
May 17-21
Fairmont Château Whistler
Whistler, British Columbia, Canada

American Society of Gene & Cell Therapy (ASGCT)
13th Annual Meeting
May 17-22
Marriott Wardman Park Hotel
Washington, D.C.

International Society for Cellular Therapy (ISCT)
16th Annual Meeting
May 23-26
Sheraton Philadelphia City Center Hotel
Philadelphia, Pennsylvania

American Society for Apheresis (ASFA)
30th Annual Meeting
May 26-29
Sheraton New Orleans Hotel
New Orleans, Louisiana

• June
8th Annual International Umbilical Cord Blood Transplantation Symposium
Cord Blood Forum
June 3-5
Hyatt Regency San Francisco at Embarcadero Center
San Francisco, California

American Society of Clinical Oncology (ASCO)
46th Annual Meeting
June 4-8
McCormick Place
Chicago, Illinois

European Hematology Association (EHA)
15th Congress
June 10-13
The Gran Via Conference Center
Barcelona, Spain

8th International Donor Registry Conference
World Marrow Donor Association (WMDA)
June 16-19
Trinity College
Dublin, Ireland

International Society for Stem Cell Research (ISSCR)
8th Annual Meeting
June 16-19
Moscone Center
San Francisco, California

FOCIS 2010
Federation of Clinical Immunology Societies (FOCIS)
June 24-28
Boston Marriott Copley Place
Boston, Massachusetts

• July
UK National Stem Cell Network (UKNSCN)
Annual Science Meeting
July 12-14
University of Nottingham, East Midlands Conference Center
Nottingham, England, United Kingdom

Cryo 2010
Society for Cryobiology
47th Annual Meeting
July 17-20
Bristol Marriott Royal Hotel
Bristol, England, United Kingdom

• August
Canadian Society of Transplantation (CST)
Annual Scientific Conference
Aug. 13-14
Vancouver Congress Centre
Vancouver, British Columbia, Canada

• September
ISCT Europe Regional Meeting
International Society for Cellular Therapy (ISCT)
Sept. 11-14
Best Western Hotel Villa Carlotta
Belgirate, Italy

 
  
Top Stories
 

Researchers identify two different types of stem cells
Two distinct types of stem cells are present in mice. According to a report in the March 5 issue of Cell Stem Cell, researchers sorted stem cells taken from mouse bone marrow into two classes, using the rate at which the cells expelled dye, in combination with other stem cell markers. When transplanted into mice lacking blood stem cells, one type of stem cell produced many more blood cells than immune cells, and vice versa.more

Researchers develop intestine from induced pluripotent stem cells
Japanese researchers have developed intestine from induced pluripotent stem cells. According to a study presented at a meeting of the Japanese Society for Regenerative Medicine, the tissue produced had a diameter of about 2 millimeters, was about 5 millimeters long and exhibited peristaltic movement. more

Endothelial cells are programmed to produce adult stem cells
Endothelial cells produce growth factors that can produce large amounts of adult stem cells over the course of weeks. According to a report in the March 5 issue of Cell Stem Cells, this indicates blood vessels are programmed to maintain and proliferate stem cells and their mature forms in adult organs. more

Induced pluripotent stem cells contain silenced genes
Scientists have uncovered a key difference in the genome-wide expression patterns of induced pluripotent stem cells and embryonic stem cells that could explain why induced pluripotent cells are slower to divide and less robust than embryonic stem cells. According to a report in the advance online edition of Nature, two genes and many microRNAs were consistently activated in the embryonic stem cells and silenced in the induced pluripotent stem cells, regardless of the original source of the induced cells. more

Cell pathway could provide way to prevent leukemia relapse
Researchers have uncovered information that may help target the stem cells that generate the immature blood cells characteristic of leukemia. According to a report in the March 26 issue of Science, targeting the Wnt/beta-catenin pathway, which leukemia stem cells need to survive, may prevent the growth and development of acute myelogenous leukemia. more

 

A Word from President John Barrett, MD

Deep in my basement, stacked between old tape recorders, cord telephones (remember them?) and other remnants of defunct technologies, is a bag of a few thousand projection slides from past lectures. One venerable magenta-faded slide reads simply “DONORS are not PATIENTS!” It was important in those days of marrow harvesting to underline the respect and care that should be awarded to individuals who were prepared to undergo the inconvenience and discomfort of the procedure. Today’s donors are as likely to be unrelated as family members, and are increasingly asked to give mobilized peripheral blood rather than the more scary marrow donation. The question arises, is it sufficient, like Blanche Dubois, to depend on the kindness of strangers submitting to the inconvenience and minimal, but definable, risk of the stem cell collection, or should we compensate them? If so, how much? Implicit in the National Organ Transplantation act of 1984 (although it does not specifically mention bone marrow transplantation) is the prohibition of payment to stem cell donors. This law is consistent with a world-wide perception that the voluntary nature of donation of blood or marrow avoids the vulnerability of obtaining bad products from donors unfit to donate, seeking to sell their blood or marrow. And, why fix something that does not appear to be broken? The figure of 10 million marrow donors worldwide does not attest to a serious shortage of unpaid volunteers.

Enter the Institute for Justice
The issue of donor payment has recently been raised in a constitutional challenge to the 1984 act, filed in Federal District Court this year by the Institute for Justice. The institute is seeking permission to proceed with a plan to compensate hematopoietic stem cell donors at the time of donation. A pilot program is proposed to determine if incentives such as scholarships, housing allowance or a charitable gift increase the number of marrow-cell donations.

ASBMT, together with the National Marrow Donor Program (NMDP), America’s Blood Centers (ABC), AABB (formerly American Association of Blood Banks), American Society of Histocompatibility and Immunogenetics, International Society of Cellular Therapy, American Society of Transplantation and the World Marrow Donor Association, have come out against any change in the law. We are concerned about the violation of a long-established code of non-compensation for blood donors set by the World Health Organization, and the possibility that paid donors may be more likely to withhold medical details and personal activities that could put both the patient and donor at risk. And, why increase the incentive for individuals to donate?

NMDP is already set to double the number of unrelated donor transplants in the next few years, and ASBMT is concerned that the capacity of the hospitals and staffs will be outstripped by the ever-increasing availability of patients with matched donors. Indeed, the logistics of handling a significant increase in the number of allogeneic stem cell transplants is the topic of an NMDP-organized conference to which hospital administrators will be invited later this year. A decision by the Department of Justice whether to change the payment rule, as it applies to stem cell donors, will be made in the next few weeks.

Whatever the decision, it is timely to review the law as it relates to stem cell donors and their recipients. Currently, the amount of donor compensation for out-of-pocket expenses and lost wages varies from state to state. We should support the application of uniform rules governing compensation for expenses for unrelated donors. What does our membership think? Please use the Reader Poll in the left-hand column. Meanwhile, nostalgic as I feel for those long-forgotten lectures in their charmingly named carousels, I am throwing them out. After all, the projectors to display them will be obsolete when the last bulb blows. For better or worse, we are in the PowerPoint age. That is some compensation. How we ever managed to pull a lecture together without electronic systems is hard now to imagine.

 
Clinical Research Legislation and Regulation
 
  • Cord Blood Workshop
    Together with the FDA and other professional organizations, the AABB presented a workshop on cord blood licensure. The event focused on understanding the FDA requirements for cord blood licensure. more

  •  
    Clinical Research Clinical Research
     
  • Stem cells in microbubbles improve blood vessel building
    Suspending stem cells derived from bone marrow in microbubbles dramatically improves the body’s ability to build new blood vessels in the upper leg. According to information presented at the Society of Interventional Radiology’s 35th Annual Scientific Meeting, the microbubbles prevent the body’s immune system from reaching and attacking the transplanted cells.more

  • Patterned surfaces affect stem cell development
    The shape of a surface used to promote stem cell development affects the differentiation of the stem cells. According to a report in the advance online edition of the Proceedings of the National Academy of Sciences, making cells assume a star shape promotes a tense cytoskeleton with the majority of cells turning into bone, while a flower shape promotes a looser cytoskeleton with the majority of cells turning into fat. more

  • Bone marrow stem cells show promise in treating asthma
    Treatment with bone marrow stem cells reduces inflammation in the airways of mice with asthma. According to a report in the advance online edition of the Proceedings of the National Academy of Sciences, further work is needed to determine whether the cells could be used to treat patients with therapy-resistant asthma. more

  • Study reveals role of stem cells in hemangioma formation
    Researchers have used stem cells to better understand hemangiomas in the laboratory. According to a report in the March 18 issue of The New England Journal of Medicine, corticosteroids (a common treatment for hemangiomas) target hemangioma stem cells specifically by shutting down production of vascular endothelial growth factor. more

  • HIV infects bone marrow, lies dormant
    Human immunodeficiency virus can infect long-lived bone marrow cells that eventually convert into blood cells. According to a report in the advance online edition of Nature Medicine, the virus is dormant in the bone marrow cells but can be reactivated and cause renewed infection when the bone marrow cells develop into blood cells. more
  •  
    Association News
     
  • Deadline for Continuing Education Credit is April 1
    Today is the deadline for claiming education credit for sessions attended at the 2010 BMT Tandem Meetings. Completed evaluations are a requirement for obtaining continuing medical education (CME) and/or contact hours for allied health professionals. Please make sure to print the certificate at the end of the online sessions. Certificates will not be mailed out. more

  • BMT Tandem Meetings abstracts are searchable online
    Abstracts accepted for the 2010 BMT Tandem Meetings were published in the February issue of Biology of Blood and Marrow Transplantation (Vol. 16, No. 2, Supplement 2) and also are indexed and accessible online. more

  • Recordings and MP3 downloads of Tandem sessions
    Most plenary and concurrent scientific session presentations of the 2010 BMT Tandem Meetings are available as audio MP3 and synchronized audio/visual downloads. more

  • If you missed the Medical Directors Conference …
    The next best thing to having been at the Medical Directors Conference at the BMT Tandem Meetings is to view it online. The conference provided an update on how the BMT community is responding to capacity, compensation and cost capture. more

  • 2010 version of RFI forms released
    The 2010 update of the ASBMT Request for Information (RFI) has been released, and the interactive forms are available online. The RFI is used for submitting transplant program data and information to third-party payers when they request it. more

  • April 1 is the deadline for the clinical research training course
    The ASBMT Clinical Research Training Course for fellows-in-training and junior faculty is returning to Park City, Utah. Applications are being accepted through April 1 for the course that will be held July 14-19.more

  • Job Connection introduces new features
    The ASBMT Online Job Connection enables job seekers to more easily upload their resumes, while employers can now identify candidates using expanded search criteria. more

  • AABB Circular of Information
    AABB (formerly the American Association of Blood Banks) recently debuted its new circular of information for the use of cellular therapy products. more

  •  
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    Copyright © 2010 American Society for Blood and Marrow Transplantation.
    All rights reserved.

    The editor for ASBMT eNews is Stephanie J. Lee, MD, MPH.
    E-newsletter services provided by the medical editors at Ascend Media, LLC.

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