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| August 2, 2010 |
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Top
Stories |
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Clinical
Research |
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Association
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BMT Tandem Meetings |
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Calendar |
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Job &
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Monthly Journal |
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eNews
Archives |
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Calendar |
• August
2011 Pan Pacific Lymphoma Conference
Aug. 11-15
The Grand Hyatt
Kauai, Hawaii
Canadian Society of Transplantation (CST)
Annual Scientific Conference
Aug. 13-14
Vancouver Congress Centre
Vancouver, British Columbia, Canada
• September
1st World Congress on Controversies in Hematology
Sept. 2-5
Rome, Italy
ISCT Europe Regional Meeting
International Society for Cellular Therapy (ISCT)
Sept. 11-14
Best Western Hotel Villa Carlotta
Belgirate, Italy
International Society for Experimental Hematology (ISEH)
39th Annual Scientific Meeting
Sept. 15-18
Melbourne Convention and Exhibition Center
Melbourne, Australia
12th International Conference on Chronic Myeloid Leukemia - Biological Basis of Therapy
ESH (European School of Haematology) and iCMLf (International Chronic Myeloid Leukemia Foundation)
Sept. 24-26
Grand Hyatt Washington
Washington, DC
American Society for Histocompatibility and Immunogenetics (ASHI)
36th Annual Meeting
Sept. 26-30
Westin Diplomat
Hollywood, Florida
• October
Fraunhofer Institute for Cell Therapy and Immunology
6th International Symposium on Neuroprotection and Neurorepair
October 1-4
Yachthafenresidenz Hohe Düne
Rostock-Warnemünde, Germany
European Society for Medical Oncology (ESMO)
35th Annual Meeting
Oct. 8-12
Milano Convention Centre
Milan, Italy
American Association of Blood Banks (AABB)
2010 Annual Meeting
Oct. 9-12
Baltimore Convention Center
Baltimore, Maryland
International Society of Hematology (ISH)
33rd World Congress
Oct. 10-13
ICC Jerusalem International Convention Center
Jerusalem, Israel
National Marrow Donor Program
2010 Council Meeting
Oct. 14-16
Minneapolis Hilton
Minneapolis, Minnesota
European School of Haematology
8th International Conference
Oct. 14-18
Cascais, Portugal
ISCT Asia-Pacific Regional Meeting
International Society for Cellular Therapy (ISCT)
Oct. 17-20
Phoenix Seagaia Resort
Miyazaki, Japan
Histiocytosis Association of America (HAA)
Oct. 18-20
Boston, Massachusetts
European Society of Gene & Cell Therapy (ESGCT)
18th Annual Congress
Oct. 22-25
Stella Polare Convention Centre
Milano, Italy
• November
World Cord Blood Congress
Nov. 4-7
Marseille, France
Neoplastic Hematopathology Update
Nov. 11-13
The Westin Diplomat Resort & Spa
Hollywood, Florida
• December
American Society of Hematology (ASH)
52nd Annual Meeting
Dec. 4-7
Orange County Convention Center
Orlando, Florida
• 2011
BMT Tandem Meetings
Combined ASBMT and CIBMTR annual meetings
Feb. 17-21
Hawaii Convention Center
Honolulu, Hawaii
• 2012
BMT Tandem Meetings
Combined ASBMT and CIBMTR annual meetings
Feb. 1-5
Manchester Grand Hyatt Hotel
San Diego, California
• 2013
BMT Tandem Meetings
Combined ASBMT and CIBMTR annual meetings
Feb. 13-17
Salt Palace
Salt Lake City, Utah
• 2014
BMT Tandem Meetings
Combined ASBMT and CIBMTR annual meetings
Feb. 19-23
Gaylord Palms
Orlando, Florida
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Top
Stories |
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Researchers warn about unproven stem cell therapies
Researchers from stem cell institutions around the world are issuing warnings about unproven stem cell therapies being marketed on the Internet and have launched a website to educate and protect patients. According to a report in the July 2 issue of Cell Stem Cell, these therapies have little or no benefit and can be dangerous and costly. 
Technique eliminates tumors after stem cell transplantation
A new technique prevents the development of tumors by using a virus to genetically modify stem cells before transplantation. According to a report in the June 22 issue of Proceedings of the National Academy of Sciences, this technique eliminates immature stem cells that can lead to tumors. 
Mesenchymal stem cells triple sepsis survival rates
Mesenchymal stem cells, found in adult bone marrow, may be useful in treating sepsis. According to a report in the advance online edition of the American Journal of Respiratory and Critical Care Medicine, use of these cells can triple survival rates in an experimental model of sepsis. 
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A Word from President John Barrett, MD
Writing this column has been a stimulus to think about the many issues which surround stem cell transplantation, and where relevant, to describe what the ASBMT does to promote the art and science of our discipline. The space does not allow for scholarly reviews and at worst the content can be so anodyne that nobody is interested to read it. In attempting to address what I think are significant issues I devoted the June letter to contrasting transplantation research through human or animal studies. I raised the issue of the appropriate role of animal models in stem cell transplantation research, how to find the right emphasis on support for human or animal transplant research and how the two areas should be coordinated to advance research in stem cell transplantation. In doing so I unwittingly instigated a storm of indignation from many prestigious animal investigators in our Society for which I sincerely apologize. A major concern was that funding for transplantation research in general is inadequate and at risk in the current financial climate and that the opinions in my letter could prejudice funding for animal research. Please therefore be assured that ASBMT and its officers are unwaveringly committed to supporting all forms of research that forward the practice of stem cell transplantation. ASBMT of course does not have a position or viewpoint on the questions I raised, and within the Society all aspects of transplant research are given equal support. Clearly, in an environment where funding for any transplant research is at a suboptimal level, the only important thing is that quality research of all types should be properly funded.
Since this column puts me in an unfair position of holding a one-sided debate, let me then redress the balance and remind those that need reminding of the highly informative transplantation research that is done outside the human arena. Historically it should not be forgotten that the entire cellular basis of marrow transplantation, GVHD and GVL was discovered in the mouse, and these key early experiments were fundamental to performing the first transplants in man. Nor should we forget that the dog has for more than 50 years served as a unique model for developing amongst other things conditioning regimens and GVHD prophylaxis and understanding graft rejection. But also today, investigators continue to successfully overcome the constraints of working with a species whose last common ancestor with man occurred 65 million years ago, by skillful design of models which are relevant to the human situation. Stem cell transplant investigators are best placed to design appropriate and relevant animal studies and know which questions can best be answered through animal experiments. In this way we have learned of the importance of host antigen-presenting cells in GVHD, and through imaging techniques have reliable in vivo models of tumor control and cell homing that cannot be studied in man in the same way. Mice have proved very useful to understanding the interaction of cytokines and growth factors during immune recovery. So there is no doubt our understanding of human alloimmunology and our ability to perform the transplants we do today stands on the shoulders of our fellow mammals. Alongside this, if we are to advance further, we also need to develop the technologies for human immunological studies, difficult as it will be. ASBMT members have been at the forefront of all aspects of transplantation biology research and the ASBMT membership is a diverse family. It is inevitable and healthy that people should hold different views. But ultimately we all have the same goal as the Society which is to promote all fields of research that improve the success of blood and bone marrow transplantation.
-- John
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Clinical Research |
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Amphibian research reveals evolution of stem cells
Researchers at the University of Nottingham have been using an axolotl to study the evolution and genetics of stem cells. The research is based on the fact that there are many similarities in the development of axolotls and mammals that provide opportunities to study the properties of embryonic stem cells and germ cells. 
Technique uses stem cells to produce dopamine neurons
A study of Parkinson’s disease will employ a new technique that uses skin cells to grow induced pluripotent stem cells that will then produce dopamine neurons. Using tissue samples from more than 1,000 patients with early stage Parkinson’s disease, researchers hope to compare the function of cells from patients with and without the disease to better understand why dopamine neurons die in patients with Parkinson’s disease.

Stem cells grown on softer gel medium
retain self-renewing properties
Growing muscle stem cells on a synthetic matrix that mimics the elasticity of real muscle allows the cells to maintain their self-renewing properties. According to a report in the advance online edition of Science Express, using softer gels as a growth medium resulted in the presence of many more cells than on the less elastic gels.

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Association
News |
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Free ASBMT membership for trainees
Postdoctoral fellows and physicians-in-training for blood and marrow transplantation are eligible for free membership in the American Society for Blood and Marrow Transplantation. During August through October, annual dues are waived for new trainees who apply for membership in the Society. The program is made possible through a grant from Otsuka America Pharmaceuticals, Inc.
13 transplant facilities now FACT accredited
Thirteen facilities received accreditation renewal during the second quarter of 2010. The complete report of accredited organizations in the second quarter is available at www.factwebsite.org.
New Edition of Cellular Therapy Standards publication
being developed
The Standards Development Steering Committee initiated the development of the 5th edition of the FACT-JACIE International Standards for Cellular Therapy Product Collection, Processing, and Administration in June in Barcelona, Spain. The purpose of this meeting, led by Carolyn Taylor, PhD, Standards Chair, was to review comments and survey responses submitted by cellular therapy programs, establish overall goals for the new edition, and coordinate subcommittee activities. The draft of the 5th edition will be available for public comment in mid-2011, with the final version being published in March 2012. Details and updates regarding the Standards development process will be provided as they become available.
Cord Blood Inspection and Accreditation Workshop to take place in conjunction with the World Cord Blood Congress
FACT will host a Cord Blood Inspection and Accreditation Workshop on Nov. 3 in conjunction with the World Cord Blood Congress in Marseille, France. This workshop will provide helpful tips to achieve accreditation, explain the new fourth edition NetCord-FACT Cord Blood Standards, and address topics such as common citations and international inspections. Whether you wish to become an inspector or prepare your bank for FACT accreditation, this workshop will provide you with valuable information!
Do the cellular therapy standards apply to cord blood units?
The answer to this increasingly common question is yes. FACT separated its cord blood banking requirements into a distinct set of standards to account for the unique and inherent differences in collection, processing, storing, and releasing cord blood units. However, the Clinical Standards still apply to clinical programs and their processing facilities using cord blood.
ASBMT redesigned website
The ASBMT website has been redesigned to meet the changing needs of the blood and marrow transplant community. This Web resource now provides easy access for all ASBMT members and the general public. Visit the new site at: www.asbmt.org.
New NetCord website launched
To meet the unique needs of the cord blood community, the International NetCord Foundation recently launched an all-new Website. This Web resource provides easy access for the entire cord blood community. Visit the new site at: www.netcord.org.
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BMT TANDEM MEETINGS |
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Registration opens for 2011 BMT Tandem Meetings in Hawaii
Online registration and housing is now open for the 2011 BMT Tandem Meetings Feb. 17-21 in Honolulu. Links to meeting registration, housing reservations, preliminary program, abstract submission and parallel conferences can all be found in one convenient location.
Abstract submission deadline is Oct. 14 for Tandem Meetings
Abstracts for the BMT Tandem Meetings in Honolulu will be accepted through Oct. 14. Invitations for oral presentation will be offered to 90 authors whose abstracts received the highest scores from the review committees. Many others will be accepted for poster presentation. ASBMT will provide travel grants to young investigators whose abstracts are accepted for oral presentation. 
Symposia process
Symposia for the 2011 BMT Tandem Meetings will be asked to adhere to new requirements and procedures for corporate support. The purpose of the new procedures is to more completely separate the scientific and educational content from commercial and other considerations and to comply with evolving rules and guidelines for continuing medical education.
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