. 

 


Stem cell transplant
improves heart
function after bypass

 


Protein identified that
regulates neural stem
cell differentiation

  
December 1, 2010
  
If you are unable to view
these articles or access the
links, please visit the ASBMT
Web Site at www.asbmt.org
to read this issue. To be
removed from this distribution
list, please see instructions at
bottom.
 
Top Stories
   
Clinical Research
 
Association News
 
BMT Tandem Meetings
 
Calendar
   
Job & Fellowship Connections
    
Monthly Journal
   
eNews Archives
 
 

 

 
 
  
Calendar

• December
American Society of Hematology (ASH)
52nd Annual Meeting
Dec. 4-7
Orange County Convention Center
Orlando, Florida

• January
Phacilitate Cell & Gene Therapy Forum 2011
Jan. 24-26
The Grand Hyatt
Washington, D.C.

Stem Cells in Development, Tissue Homeostasis and Disease
Keystone Symposia
Jan. 30-Feb. 4
Eldorado Hotel & Spa
Santa Fe, New Mexico

• February 2011
BMT Tandem Meetings
Combined ASBMT and CIBMTR annual meetings
Feb. 17-21
Hawaii Convention Center
Honolulu, Hawaii

• March
Association of Community Cancer Centers
37th Annual Meeting
March 24-26
Washington Hilton
Washington, D.C.

American Association of Tissue Banks (AATB)
15th Annual Spring Conference
March 25-29
Hyatt Regency Austin
Austin, Texas

• April
European Group for Blood and Marrow Transplantation (EBMT)
37th Annual Meeting
April 3-6
Le Palais des Congres de Paris
Paris, France

American Society of Pediatric Hematology/Oncology (ASPH/O)
24th Annual Meeting
April 13-16
Hilton Baltimore
Baltimore, Maryland

American Association for Cancer Research (AACR)
102nd Annual Meeting
April 2-6
Orange County Convention Center
Orlando, Florida

American Transplant Congress
American Society of Transplantation (AST)
April 30-May 4
Pennsylvania Convention Center
Philadelphia, Pennsylvania

• May
The IL-1 Family of Cytokines: From Basic Biology to Clinical Applications
May 8-11
Sandpearl Resort
Clearwater, Florida

Immunology 2011
American Association of Immunologists (AAI)
May 13-17
Moscone Center
San Francisco, California

American Society of Gene & Cell Therapy (ASGCT)
14th Annual Meeting
May 18-21
Seattle, Washington

International Society for Cellular Therapy (ISCT)
17th Annual Meeting
May 18-21
De Doelen Congress Centre
Rotterdam, Netherlands

11th International Symposium on Myelodysplastic Syndromes
MDS Foundation
May 18-21
Edinburgh, United Kingdom

• June
American Society for Apheresis (ASFA)
30th Annual Meeting
June 1-4
Westland Kierland Resort & Spa
Scottsdale, Arizona

American Society of Clinical Oncology (ASCO)
47th Annual Meeting
June 3-7
McCormick Place
Chicago, Illinois

International Society for Stem Cell Research (ISSCR)
ISSCR 9th Annual Meeting
June 15-18, 2011
Metro Toronto Convention Centre
Toronto, Ontario
Canada

FOCIS 2011
Federation of Clinical Immunology Societies (FOCIS)
June 23-26, 2011
Washington, District of Columbia, USA


 
  
Top Stories
 

Stem cell transplant improves heart function after bypass
Post-operative transfusion of a patient’s own stem cells improves heart function in patients who have undergone heart bypass surgery. According to information presented at the annual meeting of the American Heart Association, this stem cell infusion, given three to five months after the bypass surgery, increased left ventricular function by an average of 9 percent. more

NSAIDS target and kill mutated stem cells
Non-steroidal anti-inflammatory drugs (NSAIDS) prevent colon cancer by triggering diseased stem cells to self-destruct. According to a report in the advance online edition of Proceedings of the National Academy of Sciences, NSAIDS target stem cells that have accumulated mutations that could lead to cancer and initiate apoptosis. more

Stem cell transplants improve muscle function and mass
Working in mice, scientists determined that transplanting specific types of stem cells into leg muscles prevented the loss of muscle function and mass that normally occurs with aging. According to a report in the Nov. 10 issue of Science Translational Medicine, when transplanted with attached myofibers from donor mice, the muscle stem cells underwent a 50 percent increase in mass and a 170 percent increase in size and remained elevated throughout the lifetime of the mice. more

 

A Word from President John Barrett, MD

One of the most valued functions of the ASBMT is to provide training and support to clinical investigators and laboratory-based researchers relevant to stem cell transplantation (SCT). Providing support to research in the field of SCT keeps our Society vibrant, and focusing on the entry of newcomers to the field remains a priority even in difficult times where funding from the pharmaceutical industry has been compromised by new legislation and global financial markets. Getting the attention of our industrial partners is not achieved without some effort. Critical to this are the visits to pharmaceutical companies by the leadership, where we tell them about the ASBMT and our vision for developing SCT, exchange information and solicit support for the Society.

Visits to large multinational and smaller recent start-up companies has been a rewarding and educational experience for me. I was struck by the great diversity in the way companies were structured – sometimes we met with CEOs and sometimes with clinician-scientists. Some of the companies operate from gleaming buildings while others functioned from facilities more akin to a doctor’s surgery. Despite this diversity, it was refreshing that the industry chiefs that we meet shared with us an enthusiasm for improving stem cell transplant outcome and showed a dedication beyond that of doing business, to applying their (sometimes huge) resources to promote advances in medicine. Many people we met had long careers in clinical medicine or medical science before moving into industry, where they perceived they could make a more significant effort to advance medical treatment.

Some of these leaders of industry also join us at the annual “Corporate Council Meeting,” a mutual information exchange and a platform for strategizing partnership with industry. We discuss cell therapy and how ASBMT and industry can work with the National Institutes of Health (NIH) to achieve our common goals of delivering cell products to the clinic – one of the aims of our own Cell Therapy Task Force. It is all the more rewarding therefore to report that the New Investigator Awards and the Clinical Research Training Course are among the most popular functions of ASBMT that industry supports.

Given our commitment to research and training, ASBMT recently completed a survey of the career development of past recipients of the New Investigator Award, prepared by the Committee on Young Clinicians and Investigators. There were 29 responses from the 46 trainees, and it was gratifying to see that all the awardees were not only active as a blood and marrow transplantation (BMT) physician or researcher (or both), that nearly all were affiliated to some of the top universities in the country, and that three-quarters felt that the award was instrumental in keeping them in the BMT field. Awardees are not avaricious – most felt that the award of $50,000-150,000 was a significant and adequate amount. Most, however, preferred the option of being able to extend the award for three rather than two years. The written comments indicated satisfaction with the scheme and the general sense that the award bought time as well as the opportunity to generate the preliminary data needed for further, and often successful, funding proposals.

This survey will serve several important purposes. Firstly, it is a justification that the Society is on the right track. The field needs individuals with inquisitive minds with the interest and dedication to develop new treatments, and ASBMT can only benefit from cultivating intellectually motivated members. Secondly, we can go back to our industrial partners and show them how their support can help the BMT field. Indeed, as so much effort in developing clinical SCT requires the support of industry to bring new treatments to fruition, “big Pharma” is justified in anticipating their donations to training and career development will help ensure that qualified scientists will be available to help develop and test the next generation of treatments.

-- John

   
Clinical Research Clinical Research
 
  • Artificial environment provides all three cues
    for adult stem cell development

    Scientists have created an artificial environment for adult stem cells that simultaneously provides the chemical, mechanical and electrical cues necessary for cell growth and differentiation. According to a report in the advance online edition of Advanced Functional Materials, this is the first material reported in the scientific literature that simultaneously provides all three cues in a three-dimensional supportive environment. more

  • Neural stem cell clinical trial begins for stroke patients
    The first ever clinical trial using neural stem cell therapy has begun in the United Kingdom, according to ReNeuron Group plc. The trial, called the Pilot Investigation of Stem Cells in Stroke (PISCES) involves a neurosurgical procedure using ReN001 cells to treat patients who have become disabled due to ischemic stroke. more

  • Stem cell gene therapy resolves Wiskott-Aldrich symptoms
    Two patients with Wiskott-Aldrich syndrome saw resolution of symptoms after stem cell gene therapy. According to a report in the Nov. 11 issue of the New England Journal of Medicine, treatment involved administration of their own hematopoietic stem cells that had been altered to express the WAS protein. more

  • Protein identified that regulates neural stem cell differentiation
    A protein called Zif controls whether brain stem cells renew themselves as stem cells or differentiate into a dedicated type of neuron. According to a report in the Nov. 16 issue of Developmental Cell, Zif is important for inhibiting overgrowth of neural stem cells in fruit flies by ensuring that a proliferation factor maintains appropriate levels in neural stem cells. more
  •  
    Association News
     
  • Preparing for FDA regulation of cord blood: NMDP to pursue IND for transplant center access to unlicensed units
    In October 2011, the FDA will regulate cord blood units (CBU) as a licensed product. All units will then be categorized as licensed or unlicensed, and unlicensed units will only be accessible through an investigational new drug (IND) protocol. To facilitate access to unlicensed units from U.S. and international cord blood banks, the National Marrow Donor Program (NMDP) is planning to sponsor a centralized IND protocol, so that each transplant center will not need to develop its own IND (to access unlicensed units from banks that do not hold an IND). NMDP will be seeking transplant center feedback to develop the protocol and offering more education and training more

  • Release of request for proposals
    RFP Release Date: November 29, 2010
    Proposal Response Date: January 5, 2011 @ 2:00 p.m. Central Time
    Request for Proposal (RFP C10-0075): The Blood and Marrow Transplant Clinical Trials Network (BMT-CTN)
    is soliciting proposals from qualified U.S. laboratories to perform plasma Voriconazole pharmacokinetics testing and analysis on frozen post-doze patient samples. more

  • New NMDP website
    ExploreBMT™ is a great place to start when you are looking for information and support about blood and marrow transplantation. You can use ExploreBMT, an easy-to-search Web portal, to browse resources and services from many respected organizations. Connect to the resources that you need most throughout your transplant journey, from diagnosis through survivorship. more

  • NBF accepting applications
    The National Blood Foundation (NBF) is accepting applications for the 2011 grant cycle. Applications will be accepted for medical research projects focusing on transfusion medicine and cellular therapies. NBF offers grants of up to $75,000 total for one- and two-year projects. Applications for this year’s grant cycle are due Dec.30. Those interested in more information should visit the NBF website at www.aabb.org/NBF for the application forms.

  • Ongoing CHTC certification examinations offered
    The NMDP offers Hematopoietic Transplant Coordinator Certification exams year-round at more than 170 testing sites across the U.S. Research shows that transplant programs with Certified Hematopoietic Transplant Coordinator (CHTC) staff have more efficient unrelated donor searches. The CHTC designation is available to transplant coordinators with the equivalent of two years full-time experience with the allogeneic transplant process. Passing the CHTC exam verifies competence through an accredited certification, validates knowledge of human leukocyte antigen and donor search strategies, and promotes satisfaction through increased professional and personal growth. more

  • Recruitment will again be theme for ASH exhibits
    ASBMT (booth 228) and six other cell therapy organizations are collaborating again this year on a recruitment theme in their exhibit booths at the American Society of Hematology annual meeting. CIBMTR (booth 224), NMDP (booth 220), ISCT (booth 232), FACT (booth 234), AABB (booth 725) and NetCord (booth 230) will provide information about careers in hematopoietic cell transplantation, emphasizing the growth of the field, its opportunities and the resources that are available to young clinicians and investigators.

  • NMDP to launch transplant clinical guidelines mobile app at ASH
    A mobile phone version of the NMDP/ASBMT Clinical Guidelines for Transplant Consultation & Post-Transplant Care will be launched at the American Society of Hematology (ASH) annual meeting and exposition. Visit the NMDP booth #220 at ASH to explore the new app.
  •  
    BMT TANDEM MEETINGS
     
  • Registration for BMT Tandem Meetings
    Please remember that registration for the 2011 BMT Tandem Meetings, to be held Feb. 17-21 in Honolulu, is open. On a single Web page, navigate to meeting registration, housing reservations, preliminary program, abstract submission and parallel conferences. more

  • Housing for BMT Tandem Meetings
    Hotel reservations are first-come, first-served. Please remember that February is a popular vacation month in Hawaii. On a single Web page, navigate to meeting registration, housing reservations, preliminary program, abstract submission and parallel conferences. more
  •  
    Have you recently moved? Do we have your most current information? Please update your information online at: www.asbmt.org or send an e-mail to phyllismoliere@asbmt.org

    Copyright © 2010 American Society for Blood and Marrow Transplantation.
    All rights reserved.

    The editor for ASBMT eNews is Stephanie J. Lee, MD, MPH.
    E-newsletter services provided by the medical editors at Ascend Media, LLC.

    Do you have news, responses or opinions to share with us? Please e-mail the association office at enews@asbmt.org.


    ASBMT eNews is sent as a membership benefit of the American Society for Blood and Marrow Transplantation. If you would prefer not to receive future issues and want to remove your name from our mailing list, please reply with the word "REMOVE" in the subject line.